Rosemary essential oil microemulsion prevents DSS-induced intestinal injury in mice by modulating IL-17 signaling pathway

Therapeutic Potential of Essential Oils Against Ulcerative Colitis: A Review

“… [ 84 ] Garlic Propyl propylene disulfide, propylene disulfide, propylene trisulfide Oral administration for 7 days, 15, 25, 50 mg/kg DSS-induced colitis in rats Possesses antioxidant, anti-inflammatory and immunomodulatory properties [ 85 ] Brucea javanica Brusatol Oral administration for 7 days, 152.5 mg/kg, 305 mg/kg, 610 mg/kg DSS-induced colitis in mice Prevention of inflammation of the colon Enhancement of intestinal epithelial barrier function NF-κB signaling pathway RhoA/ROCK signaling pathway [ 86 ] Extra virgin olive Squalene, Total sterols Oral 5% extra-virgin olive oil at one-week intervals, repeated three times DSS-induced colitis in rats Good anti-inflammatory properties Inhibition of enhanced expression of STAT3, p-STAT3, COX-2 and iNOS [ 87 ] Walnut Linoleic acid, alpha-linolenic acid Oral administration for 9 days, 2.5 mL/kg DSS-induced colitis in mice Inhibition of ROS generation Mediates the NLRP3/ASC/Caspase-1 signaling pathway Regulates intestinal flora and SCFAs levels [ 88 ] Rosmarinus officinalis L L-alpha-pinene, alpha-pinene, eucalyptol Oral administration REO-microemulsion for 10 days, low-dose (125 mg/kg、250 mg/kg、500 mg/kg). DSS-induced colitis in mic L-alpha- terpineol, alpha-pinene and eucalyptol in REO-ME inhibited the release of inflammatory factors by modulating the key targets within the IL-17 signaling pathway, HSP90AA1, IKBKB, and RELA, treating UC [ 89 ] …”