Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

Abstract

Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium contributes to various diseases, such as inflammatory bowel disease, type 2 diabetes mellitus, antiphospholipid syndrome, and atherosclerosis. This review reveals the potential therapeutic role of R. intestinalis in human diseases. Patients with inflammatory bowel disease exhibit significant changes in R. intestinalis abundance, and they may benefit a lot from modulations targeting R. intestinalis. The data reviewed here demonstrate that R. intestinalis plays its role in regulating barrier homeostasis, immune cells, and cytokine release through its metabolite butyrate, flagellin and other. Recent advancements in the application of primary culture technology, culture omics, single-cell sequencing, and metabonomics technology have improved research on Roseburia and revealed the benefits of this bacterium in human health and disease treatment.

Investigation of the Ecological Link between Recurrent Microbial Human Gut Communities and Physical Activity

“…3c , Table S4). In addition, these taxa are involved in strong positive associations (Spearman correlation coefficient value > 0.5) with members of the Coprococcus and Roseburia genera that, being part of commensal bacteria producing SCFAs, primarily butyrate, exert a positive influence on intestinal barrier maintenance, colonic motility, and anti-inflammatory processes ( 38 – 40 ). Besides, additional low-abundance members appear to have significant effects on the intestinal niche, reflecting the existence of a complex and solid ecosystem.…”

Escherichia/Shigella, SCFAs, and Metabolic Pathways—The Triad That Orchestrates Intestinal Dysbiosis in Patients with Decompensated Alcoholic Cirrhosis from Western Mexico

“…As a consequence, there is an increase in the availability of alternative electron acceptors [64]. It is noteworthy that potential beneficial bacteria, such as Roseburia, Blautia, Agathobacter, and Ruminococcus, are strict anaerobes, contrary to those belonging to the Enterobacteriaceae family, which are facultative anaerobes [52,59,65,66]. Therefore, we believe that this change in the energy metabolism, which favors the oxygen in the mucosa, impacts the marked dysbiosis observed in the patients with cirrhosis described in the present study.…”

Identification of Crucial Amino Acid Residues for Antimicrobial Activity of Angiogenin 4 and Its Modulation of Gut Microbiota in Mice

“…Furthermore, we observed an increased abundance of the symbiotic bacteria Dubosiella , equol-producing bacteria Adlercreutzia , and SCFA producer Coriobacteriaceae UCG-002 bacteria, which have been reported to possess many beneficial effects ( Atkinson et al, 2005 ; Silva et al, 2020 ). However, certain SCFA-producing bacteria were decreased in Ang4-treated mice, such as Roseburia , which plays a significant role in regulating intestinal homeostasis through its metabolite, butyrate ( Nie et al, 2021 ). In the Ang4-treated mice, we noted a significant reduction in the number of pathogenic bacteria, Alistipes , which is dominant in colorectal cancer ( Parker et al, 2020 ).…”