Rosai-Dorfman disease presenting as multiple soft tissue masses

Abstract

Rosai-Dorfman disease is a rare clinical disorder which may present in many forms. While classically a disease of lymph nodes, soft tissue involvement is fairly common. Soft tissue involvement can occur without any lymphatic or systemic involvement, and may be difficult to diagnose. We describe a patient presenting with multiple soft tissue masses which on biopsy proved to be isolated cutaneous Rosai-Dorfman disease. MR imaging showed two well-defined nonspecific superficial masses that enhanced intensely. Review of the literature suggests that when this disease presents in soft tissue, multiple foci of involvement may be common. Although rare, Rosai-Dorfman disease should be considered in the differential diagnosis of patients presenting with multiple soft tissue masses.

Recurring soft tissue Rosai-Dorfman disease

“…One report highlights the striking recurrence potential in a case of abdominal wall RDD requiring five reexcisions in 12 years (4) . In a case report similar to the present case, a 40-year-old female patient with two distinct nodules in posterolateral right thigh developed a new nodule in left thigh within one year after surgical resection (8) . Whenever feasible, wide surgical margins should be performed (1,5) as chemotherapy has not proven to be useful (5,9) .…”

Soft Tissue Rosai-Dorfman Disease: Case report

“…5,11 Multifocal STRDD is extremely uncommon but recurs more frequently than a solitary lesion. 11,12 The rate of recurrence of STRDD after excision has been reported to range from 21.4-54%. 5,11 Immunohistochemistry is key to differentiating soft tissue lesions in order to determine the correct diagnosis.…”

Soft Tissue Roasi-Dorfman Disease with Features of IgG4-Related Disease in a Patient with a History of Acute Myeloid Leukemia

“…Other studies have reported female predominance for STRDD over a wide range of ages with variable-sized masses [ 5 , 6 ]. A higher recurrence rate has been suggested for STRDD with multicentric lesions compared to solitary lesions [ 7 ]. The present case was a solitary lesion at diagnosis, and the patient is receiving regular follow-up.…”