Rosai–dorfman disease: Presentation, diagnosis, and treatment

Lai, Kwong Lun; Abdullah, Victor; Ng, Kwan Shun; Fung, Ngai Sheung; Hasselt, C. Andrew van

doi:10.1002/hed.21930

Cited by 32 publications

(39 citation statements)

References 33 publications

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“…Histiocytes show abundant foamy cytoplasm, some of which with small lymphocytes in cytoplasm (emperipolesis) 3. The histiocyte will show positivity for S100, CD11c, and CD14, CD33, CD68, acid phosphatase and non-specific esterase and CD1a negativity 4 6. This patient had similar histopathological features and CD68 and S100 positivity and CD1a negativity.…”

Section: Discussionmentioning

confidence: 72%

Rosai Dorfman disease: appearances can be deceptive

et al. 2012

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A 14-year-old boy was referred to us with a history of progressive painless massive symmetrical cervical lymphadenopathy, provisionally diagnosed as lymphoma. Multiple biopsies were needed, and confirmed the diagnosis of Rosai Dorfman disease (RDD), which is a very rare benign condition. Sinus histiocytosis with massive lymphadenopathy, also known as RDD, manifests as bulky lymphadenopathy in children and young adults. Extranodal sites such as the skin, upper airways, gastrointestinal tract and central nervous system can be involved. There is a characteristic pattern of lymphoid proliferation with a thick fibrous capsule, distention of lymphoid sinuses, accumulation of plasma cells and proliferation of large, often atypical, histiocytes showing emperipolesis is characteristic. The disease is considered to be benign and usually self-limited. We emphasise the need for doing a repeat lymphnode biopsy even if the prior histopathology is suggestive of reactive lypmhnode hyperplasia in every case of persisting lymphadenopathy.

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Section: Discussionmentioning

confidence: 72%

Rosai Dorfman disease: appearances can be deceptive

et al. 2012

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“…Treatment strategies which are advocated in the literature tend to depend on the form of the disease. Corticosteroid-based schemes are currently prescribed and are reported to be effective in cases of nodal RDD or extranodal disease without bone involvement [18]. Exceptional observations of steroid-resistant extranodal soft-tissue RDD were shown to benefit from radiotherapy [19].…”

Section: Discussionmentioning

confidence: 99%

Extranodal intraosseous Rosai–Dorfman disease in the lower jaw: a case report and review of the literature

Ian¹,

Гветадзе²,

Илькаев³

et al. 2018

Opuholi golovy šei

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Section: Discussionmentioning

confidence: 99%

“…[23] The cervical region is the most commonly affected nodal site, followed by axillary, inguinal, para-aortic, and mediastinal lymph nodes. [3] Extranodal manifestation is observed in 43% of cases, with skin being the most common site. [4] Clinical morphology of cutaneous lesions is nonspecific, ranging from papules, patches, plaques, nodules to pustules, depending on the duration and depth of lesions.…”

Section: Discussionmentioning

confidence: 99%