Rosai–Dorfman disease following bone marrow transplantation for pre‐B cell acute lymphoblastic leukemia

Ambati, Srikanth R.; Chamyan, Gabriel; Restrepo, Rodrigo; Escalon, Enrique; Fort, John; Pefkarou, Athena; Khatib, Ziad; Dehner, Louis P.

doi:10.1002/pbc.21606

Cited by 19 publications

(15 citation statements)

References 18 publications

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“…31 Rosai-Dorfman disease can also be associated with autoimmune disorders such as systemic lupus erythematosus and malignancies such as lymphoma, which can serve as additional clues to aid in its diagnosis. 117,118 Key features suggestive of histiocytic neoplasms and prompting further evaluation are listed in Table 2.…”

Section: When To Suspect Histiocytic Neoplasmsmentioning

confidence: 99%

The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease

Goyal

Young

Koster

et al. 2019

Mayo Clinic Proceedings

143

160

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Histiocytic neoplasms, a rare and heterogeneous group of disorders, primarily include Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. Due to their diverse clinical manifestations, the greatest challenge posed by these neoplasms is the establishment of a diagnosis, which often leads to a delay in institution of appropriate therapy. Recent insights into their genomic architecture demonstrating mitogen-activated protein kinase/extracellular signaleregulated kinase pathway mutations have now enabled potential treatment with targeted therapies in most patients. This consensus statement represents a joint document from a multidisciplinary group of physicians at Mayo Clinic who specialize in the management of adult histiocytic neoplasms. It consists of evidence-and consensus-based recommendations on when to suspect these neoplasms and what tests to order for the diagnosis and initial evaluation. In addition, it also describes the histopathologic and individual organ manifestations of these neoplasms to help the clinicians in identifying their key features. With uniform guidelines that aid in identifying these neoplasms, we hope to improve the awareness that may lead to their timely and correct diagnosis.

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Section: When To Suspect Histiocytic Neoplasmsmentioning

confidence: 99%

The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease

Goyal

Young

Koster

et al. 2019

Mayo Clinic Proceedings

143

160

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“…Males and individuals of African descent are more frequently affected (3) . In the past reports have shown individuals developing RDD following bone marrow transplant for precursor-B acute lymphoblastic leukaemia (4) , and concurrently or after Hodgkin's and non-Hodgkin's lymphoma (5) .…”

Section: Discussionmentioning

confidence: 99%

Rosai Dorfman Syndrome (Sinus Histiocytosis with Massive Lymphadenopathy)

Dhabhar¹

2017

jmscr

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“…Moreover, two children showed a sustained response to a combination of methotrexate and mercaptopurine [33, 34]. Another two paediatric cases with nonintracranial involvement showed a good response to chemotherapy with vinblastine, prednisone, 6-mercaptopurine and methotrexate [35], and 2-chlorodeoxyadenosine (2-CdA, cladribine) [36]. …”

Section: Discussionmentioning

confidence: 99%

Mercaptopurine Treatment in an Adult Man with Orbital and Intracranial Rosai-Dorfman Disease

Arnao

Riolo

Savettieri

et al. 2016

Case Reports in Neurological Medicine

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Background. Rosai-Dorfmann disease (RDD) is a rare, idiopathic non-Langerhans cell histiocytosis, affecting children and young adults, that commonly presents as painless, massive cervical lymphadenopathy with fever, weight loss, and polyclonal hypergammaglobulinemia. Cervical lymphadenopathy and extranodal involvement are the main presentations. On the contrary, ophthalmic involvement and localisation in the central nervous system are rare. Case Report. An old man was admitted to our hospital for first seizure. Brain imaging studies revealed on the left an extra-axial thickening of the dura mater with enhancement and perilesional oedema, infiltrating the sphenoorbital fissure and an isointense mass with enhancement in the orbital region with dislocation of the optic nerve. Pathological and immunohistochemistry examination of the bioptical specimen was consistent with a diagnosis of RDD. Treatment with levetiracetam and steroids was started obtaining only remission of seizures. Because of the patient refusal of the surgical debulking, therapy with mercaptopurine was started, stopping disease progression. Conclusion. So far, very few cases of extranodal RDD with multiple CNS lesions involving the orbital region have been described. Our case is significant because it is the first case in which the efficacy of mercaptopurine treatment has been documented in an adult patient with isolated ocular and intracranial RDD.

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Rosai–Dorfman disease following bone marrow transplantation for pre‐B cell acute lymphoblastic leukemia

Cited by 19 publications

References 18 publications

The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease

The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease

Rosai Dorfman Syndrome (Sinus Histiocytosis with Massive Lymphadenopathy)

Mercaptopurine Treatment in an Adult Man with Orbital and Intracranial Rosai-Dorfman Disease

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