Rosai-Dorfman Disease: A Retrospective Analysis of 13 Cases

Rosai-Dorfman disease with spinal cord compression: a diagnostic challenge

“…The literature suggests that complete surgical resection offers a better outcome and prognosis [11,14,[18][19][20][21][22][23][24][25][26][27][28][29] with relapse in approximately 14 % of cases [18,28].…”

Mandibular Reconstruction in a Patient With Rosai–Dorfman Disease

“…Zhu et al 12 reported a retrospective analysis of 13 cases where the vast majority had extranodal manifestations of the disease, and he concludes that this disease requires an accurate diagnosis because of its rapid progression. 12,14 Since the use of microsurgical fibula flap technique first described by Hidalgo in 1989, this has been a cornerstone among surgical options for mandibular reconstruction. Fibular bone allows to plan osteotomies in relation to the orientation of the bone and its vascular pedicle.…”

“…It has been proposed in several different treatment modalities like surgical treatment, corticosteroids, gammaglobulins, but none of these treatments is definitive. 2,12 Nowadays, there are 500 cases of these diseases, and because of its low incidence, there are not comparative studies about the effectiveness of each treatment 10,12,13 .…”

Tracheobronchial Involvement of Rosai–Dorfman Disease

“…Forty-three percent of patients have extranodal involvement, including skin (11.5%), paranasal sinuses (11.3%), upper aerodigestive tract (11.3%), soft tissues (8.9%), eyes (8.5%), bone (7.8%), central nervous system (4.9%), and kidneys (2.3%). 1,11,12 Intrathoracic manifestations are rarely observed (2%), including pulmonary nodules or masses, interstitial lung disease, central airway involvement, and pleural effusion. 1,2,13–15 Patients with a chronic aggressive form affecting the kidneys, liver, or lower respiratory tract may have a poorer prognosis.…”