Rosai-dorfman disease

Nandi, Madhumita; Mondal, Rakesh; Datta, Supratim; Karmakar, Balai Chandra; Mukherjee, Krishnendu; Dhibar, Tapan

doi:10.1007/s12098-008-0063-0

Cited by 8 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 cases) Systemic symptoms Fever Anemia Fatigue None Not mentioned # of cases 3 5 1 10 9 Ref. [ 25 , 29 , 30 ] [ 3 , 24 , 27 , 29 , 31 ] [ 32 ] [ 17 , 20 , 24 , 28 , 30 , 32 – 35 ] [ 6 , 17 , 23 , 24 , 26 , 36 – 38 ] Lesion location Lymph nodes Bone Brain Other # of cases 18 8 5 6 Ref. [ 17 , 22 , 25 , 27 – 36 , 39 , 40 ] [ 6 , 22 , 24 , 34 , 37 , 40 ] [ 20 , 24 , 26 , 38 , 39 ] [ …”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature

et al. 2016

View full text Add to dashboard Cite

BackgroundRosai-Dorfman disease (RDD) is a rare form of histiocytosis characterized by histiocyte proliferation within lymph nodes and extranodal tissue. Here we report an unusual presentation of RDD in an Italian toddler. Moreover, we reviewed the pediatric case reports published between 2004 and 2014, focusing in particular on medical therapy.Case presentationWe report the case of a 14-month-old child who developed a progressive swelling of the right parotid, associated with systemic symptoms and abnormal blood tests. During diagnostic work-up, cervical, intraparotid, and unilateral hilar lymphadenopathies were found. Histopathological and immunohistochemistry studies of a cervical lymph node biopsy established the diagnosis of RDD, with positive PCR for Epstein - Barr virus on the biopsy specimen. Oral steroid therapy was started with progressive reduction in size of all lesions, resolution of systemic symptoms, and normalization of blood tests.ConclusionRDD is generally considered a benign and self-limiting form of histiocytosis, usually associated with favorable prognosis. However, complications are not infrequent and fatal cases were reported even in children. Efforts should be made to establish the best therapeutic strategy for this disease, as no well-defined guidelines exist. Finally, RDD should be included in differential diagnosis of lymphadenopathy and parotid swelling even in very young children.Electronic supplementary materialThe online version of this article (doi:10.1186/s12887-016-0595-9) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Role of radiotherapy and chemotherapy is on trial in case of extensive lesions 9. Although the etiology of RDD is unknown, the leading hypothesis is that it is of infectious origin 110. It has been suggested that RDD may be linked to Parvovirus infection, as Parvovirus B19 capsid proteins have been isolated in some cases 10…”

Section: Discussionmentioning

confidence: 99%

“…The extranodal involvement occurs in 25% of cases 1. Osseous involvement as the only manifestation is unusual 2.…”

Section: Introductionmentioning

confidence: 99%

Extranodal Rosai–Dorfman disease in a carpal bone

Tripathy

Misra

Sahu

et al. 2012

IJOO

View full text Add to dashboard Cite

We report a case of extranodal Rosai–Dorfman Disease (RDD) of the scophoid in a 52-year old female. The patient presented with pain, swelling, and tenderness on deep palpation of the left wrist. Clinicoradiological diagnosis was osteomyelitis or tenosynovitis and curettage was performed on the lytic lesion over scaphoid to procure tissue. Diagnosis was made by histomorphology supported by immunostaining. The patient was managed conservatively with resolution of the lesion.

show abstract

“…Recently, the number of reports showing the usefulness of oral steroid for the treatment of RDD has been increasing. However, the steroid doses reported for RDD have been 1–2 mg/kg per day of prednisolone, 2–4 70 mg/day of prednisolone, 5 60 mg/kg of prednisolone (oral pulse therapy), 6 8–20 mg/day of dexamethasone, 7,8 and 500 mg/day of i.v. methylprednisolone, 9 all of which are considerably higher than the dose applied in this patient.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of Rosai–Dorfman disease with low‐dose oral corticosteroid

Oka¹,

Kamo²,

Goto³

et al. 2009

The Journal of Dermatology

View full text Add to dashboard Cite

We present herein a Japanese case of Rosai-Dorfman disease (RDD) in which cutaneous manifestations completely remitted after treatment with low-dose oral corticosteroid. A 69-year-old Japanese man presented with a 1-year history of enlarged submandibular lymph nodes and subsequent nasal and pharyngeal bleeding. RDD was diagnosed based on biopsy results from a lymph node in the left parotid region. The patient had also noted several skin eruptions that repeatedly appeared and disappeared on the face and arms. Biopsies were taken from skin eruptions on the face and cuboidal fossa. Both biopsy specimens showed dense, well-demarcated infiltration of histiocytes, lymphocytes and multinucleated giant cells from just under the epidermis to the subcutaneous tissue. These histiocytes were positive for CD68 and S-100, but negative for CD1a, and some displayed emperipolesis. Given the histopathological findings and the fact that the patient was suffering from RDD, skin lesions were diagnosed as cutaneous manifestations of RDD. Cutaneous lesions gradually began to persist concomitant with enlargement of extranodal lymphadenopathy in the nasopharyngeal area. Increasing respiratory obstruction prompted a trial with oral prednisolone commencing at 0.4 mg/kg per day. Both the lymphadenopathy and skin lesions responded quickly. Within 3 months, all his skin lesions disappeared completely with almost complete resolution of lymphadenopathy. Twelve months after the beginning of oral prednisolone therapy, slight recurrence of mucosal and cutaneous lesions appeared, but disappeared quickly with an increase in prednisolone to 0.3 mg/kg per day. Low-dose prednisolone appeared very effective in the case of RDD.

show abstract

Rosai-dorfman disease

Cited by 8 publications

References 6 publications

Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature

Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature

Extranodal Rosai–Dorfman disease in a carpal bone

Successful treatment of Rosai–Dorfman disease with low‐dose oral corticosteroid

Contact Info

Product

Resources

About