Rosacea: Treatment targets based on new physiopathology data

Cribier, B.

doi:10.1016/j.annder.2021.11.001

Cited by 13 publications

(16 citation statements)

References 99 publications

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“…There is now increasing evidence that rosacea is an inflammatory disease characterized by an abnormal innate immune response, major vascular changes, and increased colonization by Demodex mites, along with a genetic predisposition and multiple external aggravating factors [1]. Overall, erythematoustelangiectatic rosacea is characterized mainly by vascular components, then, the findings of the present work are in line with the botulinum toxin type A mechanisms of action described in the review by Rho, Gil [9]:…”

Section: Discussionsupporting

confidence: 84%

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Use of botulinum toxin type A associated with nonthermal microneedling for treating erythematoustelangiectatic rosacea: A case report

Soares¹,

Antunes²,

Martins³

2022

J Clin Images Med Case Rep

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Treatments for rosacea control the pathology for a short period, requiring daily maintenance with topical and oral cosmetics. This research aimed to report the result of treatment of microneedling associated with botulinum toxin type A in a 37-years old female affected by erythematoustelangiectatic rosacea. The procedure consisted in applyingbotulinum toxintype A (100 UI diluted in 4 ml of saline, via drug delivery), with the electric nonthermal microneedling device. It was performed in 2 sessions, with an interval of 15 days.

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Section: Discussionsupporting

confidence: 84%

“…Rosacea is an inflammatory disease of sebaceous glands affecting the cheeks, nose, chin, and forehead which present persistent facial erythema, paules, pustules, telangiectasia, recurrent flushing, among other symptoms [1]. There is no standard protocol for its treatment, albe it several treatment methods have been suggested.…”

Section: Introductionmentioning

confidence: 99%

Use of botulinum toxin type A associated with nonthermal microneedling for treating erythematoustelangiectatic rosacea: A case report

Soares¹,

Antunes²,

Martins³

2022

J Clin Images Med Case Rep

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“…2 The first-line treatment of MS, described as beneficial, includes drugs typically used in rosacea (permethrin, brimonidine, and metronidazole), acne (oral isotretinoin, systemic doxycycline), oral antihistamines (e.g., ketotifen, desloratadine), and systemic corticosteroids. 2,3,9,23,[29][30][31][32] The combination therapy of low-dose isotretinoin (below 0.5 mg/kg) plus antihistamine is the treatment of choice. In the resistant cases, multiple additional options can be considered: intralesional triamcinolone, complex decongestive therapy, omalizumab, CO 2 laser blepharoplasty with surgical eyelid debulking in cases of prominent eye-edema with bulking eyelids causing visual field narrowing.…”

Section: Discussionmentioning

confidence: 99%

Omalizumab in the treatment of Morbihan syndrome in an adolescent girl – case report and literature review

Mazurek-Durlak,

Mularczyk,

Kwinta

et al. 2023

Allergol Immunopathol

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Morbihan syndrome (MS) is characterized by solid facial edema, usually related to rosacea or acne vulgaris. The facial edema deforms the patient’s features, can impair peripheral vision, and affects quality of life. Its pathophysiology remains unclear. The disease usually has a slow and chronic course. MS most commonly affects middle-aged Caucasian men with rosacea and is rare in people below 20 years of age. MS is a diagnosis of exclusion. There is no standard treatment for MS, though systemic isotretinoin and antihistamines are mainly used. We present the case of an adolescent girl with MS nonresponding to 19 months of isotretinoin treatment with add-on antihistamines. Therapy with monthly administration of omalizumab (anti-IgE) for 6 months was an effective therapeutic option, improving the quality of life. Our case is the second description of omalizumab use in Morbihan syndrome, the first in an adolescent.

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“…Various investigative techniques have been utilized to understand the intricate role of macrophages in the disease ( 121 ). One significant method used in this pursuit is immunohistochemistry ( 122 ). Immunohistochemistry allows scientists to visualize and assess the distribution and activation state of macrophages in rosacea-affected skin tissue samples using fluorescent or enzyme tags ( 123 ).…”

Section: Progress and Challenges In Macrophage-targeted Therapies For...mentioning

confidence: 99%

The role of macrophages in rosacea: implications for targeted therapies

Liu,

Zhou,

Chu

et al. 2023

Front. Immunol.

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IntroductionRosacea, a widespread chronic skin condition, may be influenced by macrophages, key immune cells in the skin, although their exact role is not yet fully understood. This review delves into the function of macrophages, their potential contribution to rosacea pathogenesis, current treatments, and promising macrophage-targeted therapies. It concludes by identifying knowledge gaps and potential areas for future rosacea research.MethodLeveraging systematic and narrative literature review techniques, we conducted a comprehensive search of databases such as PubMed, Embase, and Web of Science. Utilizing keywords like “rosacea” and “macrophages”, we targeted English articles from the last 5 years (2018-2023). We manually checked reference lists of relevant articles for additional studies. We included only articles emphasizing macrophages’ role in rosacea and/or the development of related therapies and published within the specified timeframe.ResultsThe systematic search of electronic databases yielded a total of 4,263 articles. After applying the inclusion and exclusion criteria, 156 articles were selected for inclusion in this review. These articles included original research studies, review articles, and clinical trials that focused on the role of macrophages in rosacea and/or the development of macrophage-targeted therapies for the disease. The selected articles provided a comprehensive and up-to-date overview of the current state of research on macrophages in rosacea, including their function in the skin, the potential mechanisms through which they may contribute to rosacea pathogenesis, and the current treatments and therapies available for the disease. Additionally, the articles identified gaps in knowledge regarding the role of macrophages in rosacea and suggested potential areas for future research.ConclusionThis literature review emphasizes the important role that macrophages, vital immune cells in the skin, may play in the pathogenesis of rosacea, a common chronic inflammatory skin disorder. The selected studies suggest potential mechanisms by which these cells might contribute to rosacea progression, although these mechanisms are not yet fully understood. The studies also spotlight current rosacea treatments and illuminate the promising potential of new macrophage-focused therapies. Despite these insights, significant gaps persist in our understanding of the precise role of macrophages in rosacea. Future research in this area could provide further insights into the pathogenesis of rosacea and contribute to the development of more effective, targeted therapeutic strategies.

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Rosacea: Treatment targets based on new physiopathology data

Cited by 13 publications

References 99 publications

Use of botulinum toxin type A associated with nonthermal microneedling for treating erythematoustelangiectatic rosacea: A case report

Use of botulinum toxin type A associated with nonthermal microneedling for treating erythematoustelangiectatic rosacea: A case report

Omalizumab in the treatment of Morbihan syndrome in an adolescent girl – case report and literature review

The role of macrophages in rosacea: implications for targeted therapies

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