Rosacea and subsequent diagnosis for Parkinson's disease: a large, urban, single center, <scp>US</scp> patient population retrospective study

Mathieu, R; Guido, Nicholas; Ibler, Erin; Serrano, Linda; Rangel, Stephanie M.; Schlosser, Bethanee J.; West, Dennis P.; Laumann, Anne E.; Nardone, Beatrice

doi:10.1111/jdv.14638

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…For ages, doctors have been using tetracycline in the treatment of rosacea. These drugs offer neuroprotection delaying the onset of PD, as seen in the mouse PD model [ 25 ], and this finding is consistently seen in other studies [ 18 , 19 ].…”

Section: Reviewsupporting

confidence: 66%

“…Another large retrospective study in the US using the electronic medical record of 803,005 adult patients (17,682 with rosacea diagnosis) followed over more than five years showed an increased risk of PD in rosacea patients (OR=1.39;95% CI:1.04-1.85; p<0.02).The age at rosacea diagnosis was higher in patients who ultimately got PD than those rosacea patients who did not get PD. Out of rosacea patients, those exposed to tetracycline showed no relation between rosacea and PD, whereas those not exposed to tetracyclines showed the relation [ 19 ]. Many other studies hypothesize the possible mechanisms linking the PD and rosacea [ 20 - 22 ].…”

Section: Reviewmentioning

confidence: 99%

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Parkinson’s Disease and Its Dermatological Associations: Is Your Skin Whispering You a Diagnosis?

Shah

Sagar

Alhumaidi

et al. 2020

Cureus

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Parkinson's disease (PD) is a neurodegenerative disease characterized clinically by the triad of resting tremor, rigidity, and bradykinesia. Although PD is primarily known for motor disturbance, 98.6% of patients experience one or more non-motor symptoms at all stages of the disease. Dermatological disorders are discussed as common non-motor associations of PD since the 20th century. Many studies have shown that patients of PD are predisposed to skin disorders. This article is a traditional review done to analyze the association between PD and its dermatological manifestations. We did a literature search using six keywords in the PubMed database and took the relevant articles published in the last 10 years. We reviewed more than 100 articles, which also included animal studies. On meticulous review, we observed an increased incidence of certain skin disorders like seborrheic dermatitis, bullous pemphigoid, rosacea, and melanoma in patients of PD. These disorders share either common risk factors or underlying mechanisms revolving around genetics, immunology, inflammation, and pathophysiology of PD, but the exact causation yet seems obscured. We believe that this opens a horizon for more research in the link between the skin and nervous system. We also emphasize that the dermatologists, neurologists and general physicians should address the cutaneous disorders in PD timely, educate their patients, help them lessen the psychosocial distress, and improve their quality of life.

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Section: Reviewsupporting

confidence: 66%

Section: Reviewmentioning

confidence: 99%

Parkinson’s Disease and Its Dermatological Associations: Is Your Skin Whispering You a Diagnosis?

Shah

Sagar

Alhumaidi

et al. 2020

Cureus

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“…No significant sex differences were noted. In a subsequent US study, Mathieu and colleagues [166] replicated the findings from the Danish study.…”

Section: Rosaceamentioning

confidence: 81%

“…Rosacea is a common inflammatory skin disorder (prevalence of up to 10% or higher in Caucasians) characterized by the presence of a fixed centrofacial erythema and phymatous changes (skin thickening and irregular surface nodularity) and/or a range of "major" (flushing, papules and pustules, telangiectasia, and ocular manifestations), and "secondary" (burning sensation, stinging sensation, edema, dryness, and ocular manifestations) features affecting primarily the convexities of the central face [164]. Evidence for a link between rosacea and PD is so far limited to 3 main studies [63,165,166]. In a cohort of patients with PD, Fischer and colleagues in 2001 first noted a relatively high prevalence of concomitant rosacea (18.8%) and flushing (31.9%), of which the latter in some cases could have represented flushing due to autonomic dysfunction in PD and not rosacea per se [63].…”

Section: Rosaceamentioning

confidence: 99%

Parkinson's disease and skin

Niemann

Billnitzer

Jankovic

2021

Parkinsonism & Related Disorders

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Parkinson's disease is associated with a variety of dermatologic disorders and the study of skin may provide insights into pathophysiological mechanisms underlying this common neurodegenerative disorder. Skin disorders in patients with Parkinson's disease can be divided into two major groups: 1) non-iatrogenic disorders, including melanoma, seborrheic dermatitis, sweating disorders, bullous pemphigoid, and rosacea, and 2) iatrogenic disorders related either to systemic side effects of antiparkinsonian medications or to the delivery system of antiparkinsonian therapy, including primarily carbidopa/levodopa, rotigotine and other dopamine agonists, amantadine, catechol-O-methyl transferase inhibitors, subcutaneous apomorphine, levodopa/carbidopa intestinal gel, and deep brain stimulation. Recent advances in our understanding of the role of α-synuclein in peripheral tissues, including the skin, and research based on induced pluripotent stem cells derived from skin fibroblasts have made skin an important target for the study of Parkinson's disease pathogenesis, drug discovery, novel stem cell therapies, and diagnostics.

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“…Besides, patients treated with tetracycline showed a decreased risk of Parkinson’s disease [ 7 ]. A cohort study conducted in the United States using the electronic medical records of 803,005 individuals also found an increased risk of Parkinson’s disease in patients with rosacea (odds ratio (OR): 1.39; 95% CI: 1.04–1.85) compared with the control population [ 8 ]. We summarize recent nationwide population-based cohort and case–control studies analyzing the risk of each neurologic disorder in patients with rosacea in Table 1 .…”

Section: The Risk Of Neurologic Diseases In Rosaceamentioning

confidence: 99%

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Woo

Han

Kim

et al. 2020

IJMS

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Rosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated. The purpose of this review was to provide the most up-to-date evidence on the risks of neuropsychiatric and gastrointestinal comorbidities in patients with rosacea. Moreover, the molecular pathomechanisms associated with neuropsychiatric and gastrointestinal comorbidities in patients with rosacea were evaluated based on recent studies. This review was also intended to focus more on the role of the gut–brain–skin axis in the association of neuropsychiatric and gastrointestinal comorbidities in rosacea.

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Rosacea and subsequent diagnosis for Parkinson's disease: a large, urban, single center, US patient population retrospective study

Cited by 10 publications

References 9 publications

Parkinson’s Disease and Its Dermatological Associations: Is Your Skin Whispering You a Diagnosis?

Parkinson’s Disease and Its Dermatological Associations: Is Your Skin Whispering You a Diagnosis?

Parkinson's disease and skin

Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

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