Rosacea and its association with enteral microbiota in Korean females

Nam, Jae Hui; Yun, Yeojun; Kim, Han Saem; Kim, Han Na; Jung, Hyun Ae; Chang, Yoosoo; Ryu, Seungho; Shin, Hocheol; Kim, Hyung Lae; Kim, Won Serk

doi:10.1111/exd.13398

Cited by 62 publications

(57 citation statements)

References 34 publications

(44 reference statements)

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“…In the intestine, Peptococcaceae family unknown genus and Methanobrevibacter were reduced and Acidaminococcus and Megasphaera were elevated in rosacea subjects compared to rosacea-free individuals, even after adjustment for covariates [11]. Contrary to what was anticipated, the gut bacteria linked to rosacea differed from the blood bacteria that were altered in rosacea subjects in this study.…”

mentioning

confidence: 55%

“…Rosacea is associated not only with various gastrointestinal diseases, but also with gut dysbiosis [9-11]. Indeed, our previous cross-sectional study demonstrated that the gut microbiota was altered in rosacea subjects [11].…”

mentioning

confidence: 99%

“…Indeed, our previous cross-sectional study demonstrated that the gut microbiota was altered in rosacea subjects [11]. Given the aberrant composition of the gut microbiota in rosacea subjects and the putative role of the blood microbiota in comorbid diseases, there may be a connection between the gut, blood, and skin inflammation.…”

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confidence: 99%

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Characterization of the Blood Microbiota in Korean Females with Rosacea

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Characterization of the Blood Microbiota in Korean Females with Rosacea

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“…The non-negligible frequency of aci1 in the human gut microbiome and its presence across at least three continents is of medical relevance for at least two reasons, even when the gene is not (yet) found in pathogens. First, Acidaminococcus and other Negativicutes have been found in clinical samples and may be involved in polymicrobial infections like abscesses (Jumas-Bilak et al, 2007;Tito et al, 2017), dysbiotic conditions like vaginosis (Zozaya-Hinchliffe et al, 2008), or complex disorders (Gough et al, 2015;Nam et al, 2018). Second, the secretion of betalactamases into the gut by commensal bacteria in response to beta-lactam antibiotics prescribed against bacterial pathogens could provide resistance for nearby bacteria, including pathogens, by collective resistance, sometimes termed indirect or passive resistance (Stiefel et al, 2015;Sorg et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

ACI‐1 beta‐lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages

Rands

Starikova

Brüssow

et al. 2018

Environmental Microbiology

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Antibiotic resistance is increasing among pathogens, and the human microbiome contains a reservoir of antibiotic resistance genes. Acidaminococcus intestini is the first Negativicute bacterium (Gram-negative Firmicute) shown to be resistant to beta-lactam antibiotics. Resistance is conferred by the aci1 gene, but its evolutionary history and prevalence remain obscure. We discovered that ACI-1 proteins are phylogenetically distinct from beta-lactamases of Gram-positive Firmicutes and that aci1 occurs in bacteria scattered across the Negativicute clade, suggesting lateral gene transfer. In the reference A. intestini RyC-MR95 genome, we found transposons residing within a tailed prophage context are likely vehicles for aci1's mobility. We found aci1 in 56 (4.4%) of 1,267 human gut metagenomes, mostly hosted within A. intestini, and, where could be determined, mostly within a consistent mobile element constellation. These samples are from Europe, China and the USA, showing that aci1 is distributed globally. We found that for most Negativicute assemblies with aci1, the prophage observed in A. instestini is absent, but in all cases aci1 is flanked by varying transposons. The chimeric mobile elements we identify here likely have a complex evolutionary history and potentially provide multiple complementary mechanisms for antibiotic resistance gene transfer both within and between cells.

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“…75 Gut microbiota Table 1 Changes observed in gut microbiome composition in the course of selected skin diseases. 51,69,70,85,106,107 alterations may also contribute to insulin resistance and thus higher insulin serum levels. 76,77 Patients with decreased gastric acid secretion may suffer from the disruption of the defence mechanisms preventing the excessive bacterial colonization of small bowel.…”

Section: Acne Vulgarismentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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Rosacea and its association with enteral microbiota in Korean females

Abstract: Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain. We aimed to investigate the link between rosacea and enteral microbiota.

Cited by 62 publications

References 34 publications

Characterization of the Blood Microbiota in Korean Females with Rosacea

Characterization of the Blood Microbiota in Korean Females with Rosacea

ACI‐1 beta‐lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

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