Rosa platyacantha Schrenk from Kazakhstan—Natural Source of Bioactive Compounds with Cosmetic Significance

Abstract

Plants belonging to the Rosa genus are known for their high content of bioactive molecules and broad spectrum of healing and cosmetic activities. Rosa platyacantha Schrenk is a wild-type species abundant in the mountainous regions of Kazakhstan. The phytochemical composition as well as the bioactivity of R. platyacantha extracts have not been fully investigated to date. In this study, various parts of R. platyacantha plant, collected in Almaty region, Kazakhstan, were used to prepare five hydroalcoholic extracts (R1–R5). The extracts were compared for the content of phytochemicals and selected biological activities, which are important for the potential cosmetic application of R. platyacantha. Extract R3, prepared from flower buds, showed the most significant antioxidant and tyrosinase inhibitory potential, decreasing the monophenolase and diphenolase activities of tyrosinase. Extract R3 showed also collagenase inhibitory activity and cytotoxicity against human melanoma cells A375, being less cytotoxic for noncancerous skin keratinocytes HaCaT. Analysis of fractions E and F, obtained from R3 extracts, revealed that quercetin, kaempferol, rutin, and their derivatives are more likely responsible for the tyrosinase inhibitory properties of R. platyacantha extracts.

Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper

“…The inhibition of the monophenolase and diphenolase activities of mushroom tyrosinase was performed as previously described [19,20]. For the monophenolase inhibitory assay, 100 mM phosphate buffer (PBS, pH = 6.8, 80 µL) was mixed with 20 µL of Piper methanolic extracts (10 µg/mL), piperine (10 µg/mL) or kojic acid (10 µg/mL).…”

“…The inhibition of murine tyrosinase activity was assessed using B16F10 cell lysate, as previously described [19,20]. The B16F10 cells (8 × 10 6 ) were lysed for 1 h with 1% Triton X-100 in PBS (5 mL) in an ultrasound ice-cold water bath.…”

“…Tyrosinase is a key enzyme of melanogenesis, catalyzing the rate-limiting conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA) and subsequently to dopaquinone. Numerous plant extracts have previously been shown to exert tyrosinase inhibitory effects [20,[57][58][59]. The influence on the monophenolase activity was investigated with mushroom tyrosinase (by adding L-tyrosine as substrate), whereas the influence on the diphenolase activity was evaluated with both mushroom and murine tyrosinase (by adding L-DOPA as substrate) (Figure 5).…”

An Update on the Function, Biosynthesis and Regulation of Floral Volatile Terpenoids

“…Plant volatile compounds (VOCs) biosynthesis occurs in almost all plant organs, including the roots, stems, leaves, flowers, fruits and seeds. They are widely used in perfumes, cosmetics and medicines, and seem promising for use in therapeutic gardens because some possess anxiolytic properties [1,2]. VOCs are lipophilic liquids with low molecular weights and high vapor pressures at ambient temperatures.…”

Biological Activities of Natural Products II

“…Sabitov et al [ 9 ] analyzed the phytochemicals in hydroalcoholic extracts of different organs of Rosa platyacantha wild-grown in the mountain area in Kazakhstan. The extract from closed flowers (flower buds) possessed the highest antioxidant activity (DPPH and ABTS tests) and the highest tyrosinase inhibitory potential.…”