Rosa canina L. – new possibilities for an old medicinal herb

Abstract

Health beneficial properties of Rosa canina species are mainly attributed to rose hips, while the leaves are usually discarded as waste. In the present study we investigated chemical constituents as well as antimicrobial and antibiofilm potential of R. canina methanolic leaf extract. Chemical analysis showed that dominant phenolic compounds are quercetin and isorhamnetin derivatives (isoquercetin and isorhamnetin-3-O-rutinoside). Among the tested bacteria, Pseudomonas aeruginosa and Salmonella typhimurium were the most susceptible to the activity of R. canina leaf extract with MIC and MBC values both 0.009 mg mL −1 . For most of the bacterial strains investigated the extract showed significantly higher activity compared to the used standard compounds streptomycin and ampicillin. Also the tested extract powerfully inhibited in vitro biofilm growth in Pseudomonas aeruginosa, Staphylococcus aureus, Leishmania monocytogenes and Escherichia coli at sub MIC-levels. With concentrations equal to 1/4 and 1/8 of MIC values biofilm growth of P. aeruginosa and E. coli was inhibited by 90%. The obtained results are significant for a wider and efficient use of R. canina leaves.

Characterization of Free and Bound Phenolic Acids and Flavonoid Aglycones in Rosa rugosa Thunb. Leaves and Achenes Using LC–ESI–MS/MS–MRM Methods

“…However, our study revealed the presence of 3-O-methylkaempferol in rose leaves. Similarly, isorhamnetin and its glucosides were noted in rugosa rose bee pollen [38] and in the leaves, petals, and fruits of other rose species [16,18,39]. However, our report describes the presence of isorhamnetin in R. rugosa leaves.…”

“…They are treated mainly as unused plant material obtained in large quantities during cultivation of rose hips and/or petals. In light of some previous studies on the composition and biological activity of rose leaves and hips, it seemed reasonable to know if these rose organs are a valuable source of polyphenols for potential use [15,[17][18][19][20]. The analyses were conducted for hydrolyzed and non-hydrolyzed samples to compare qualitatively and quantitatively free and conjugated phenolic compounds in R. rugosa leaves (LF) and achenes (true fruits, FRU).…”

“…The large amounts of rose leaves and achenes constituting an interesting raw material for potential application are obtained from rose plantations every year. Although these rose organs are still being treated as plantation by-products and often discarded without any utilization, the interest in their potential use for commercial purposes (e.g., for preparation of nutraceuticals, functional foods, or pharmaceutical products) has continued to grow in recent years [14][15][16][17][18][19][20][21]. Moreover, rose leaves have been used in folk medicine to cure bronchitis and were found to exhibit anti-angiogenic, anti-inflammatory, and anti-nociceptive activities [22,23].…”

Characterization of Rosa canina Fruits Collected in Urban Areas of Slovakia. Genome Size, iPBS Profiles and Antioxidant and Antimicrobial Activities

“…The extracts were effectively inactive against C. perfringens growth. Previously, the antimicrobial activity of R. canina leaf extract was evidenced against P. aeruginosa and S. typhimurium [27]. In another study with R. canina-mediated biogenic silver nanoparticles, MIC and antibacterial activity ranged between 16 µg/mL and 256 µg/mL for Bacillus cereus, Enterococcus hirae, Staphylococcus aureus, Escherichia coli, Legionella pneumophila, Candida albicans, and P. aeruginosa [28].…”

The use of rose hips in the technology of alcoholic beverage

“…Целью работы является разработка рецеп-туры пивного напитка с использованием нетради-ционного лекарственного сырья -шиповника [7][8][9].…”