ROS Scavenging Graphene‐Based Hydrogel Enhances Type H Vessel Formation and Vascularized Bone Regeneration via ZEB1/Notch1 Mediation

Zhou, Junpeng; Li, Yongwei; He, Jiahui; Liu, Liying; Hu, Shugang; Guo, Meng; Liu, Tun; Liu, Junzheng; Wang, Jiaxin; Guo, Baolin; Wang, Wei

doi:10.1002/mabi.202200502

Cited by 7 publications

(2 citation statements)

References 65 publications

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“…Excessive in ammation and ROS can prolong the in ammatory period during wound healing, resulting in wound delayed or non-healing 32 . Therefore, wound repair materials should have certain ROS scavenging ability.…”

Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Electroactive, Antibacterial and Antioxidative Composite Membranes with Incorporation of Gold Nanoparticles and Antibacterial Peptides for Enhancing Skin Wound Healing

Dong,

Wang,

Wang

et al. 2023

Preprint

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Large skin wound is one of the most important health problems in the world. Skin wound repair and tissue regeneration is a complex process involving many physiological signals, and effective wound healing remains a huge clinical challenge. Therefore, there is an urgent need for a strategy to rapidly kill bacteria, promote cell proliferation and accelerate wound healing. At present, electrical stimulation (ES) is often used in clinical treatment of skin wound, which can simulate endogenous biological current of the body and accelerate the repair process of skin wound. However, a single ES strategy is difficult to cover the entire wound area, which may lead to unsatisfactory therapeutic effect. To overcome this deficiency, it is essential to develop a collaborative treatment strategy that combines ES with other treatments. In this study, gold nanoparticles and antibacterial peptides Os were loaded on the surface of poly(lactic-co-glycolic acid) (PLGA) material through the reducibility and adhesion of polydopamine (PDA), and realized the improvement of the electrical activity, anti-inflammatory, antibacterial and biocompatibility of the polymer material. At the same time, this composite membrane material (Os/Au-PDA@PLGA) combined with ES was used in wound therapy to improve wound healing rate. The results show that the new wound repair material has good biocompatibility and can effectively promote cell proliferation and migration. Through the combined application of gold nanoparticles and antibacterial peptides Os, the polymer materials have more efficient bactericidal and antioxidant effects. The antibacterial experiment results showed that gold nanoparticlescould further enhance the antibacterial activity of antibacterial peptides. Furthermore, the Au/Os-PDA@PLGA compositemembrane has good hydrophilicity and electrical activity, which can provide a more favorable cell microenvironment for wound healing. In vivo studies using a full-layer defect model in rats showed that the Au/Os-PDA@PLGA composite membrane had a better therapeutic effect than the pure PLGA material. More importantly, the combination of Au/Os-PDA@PLGA composite with ES significantly accelerated the rate of vascularization and collagen deposition, and promoted wound healing, compared with non-ES controls. Therefore, the combination of Au/Os-PDA@PLGA composite membranewith ES may provide a new strategy for the effective treatment of skin wound.

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Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Electroactive, Antibacterial and Antioxidative Composite Membranes with Incorporation of Gold Nanoparticles and Antibacterial Peptides for Enhancing Skin Wound Healing

Dong,

Wang,

Wang

et al. 2023

Preprint

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“…Zhou et al utilized a reduced graphene oxide hydrogel (GM/Ac-CD/rGO) in a mouse cranial defect model. They found that the hydrogel could enhance the immune microenvironment by neutralizing free oxygen radicals (ROS) around the cranial defect through the electron transfer capacity of reduced GO [ 101 ]. In a study by Hang Xue et al, it was demonstrated that quaternized chitosan-graphene oxide-polydopamine nanocomposites (QCS-GO-PDA) significantly scavenged ROS and reduced inflammatory responses.…”

Section: Potential Mechanisms and Related Signaling Pathways Of Graph...mentioning

confidence: 99%

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Zhou,

Chen,

Zhang

et al. 2024

Nanomaterials

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Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures and impair their healing ability. Conventional internal fixation therapies are ineffective in the treatment of osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing osteoporotic fractures. It has been demonstrated that nanomaterials, particularly graphene oxide (GO), possess unique advantages in tissue engineering due to their excellent biocompatibility, mechanical properties, and osteoinductive abilities. Based on that, GO-nanocomposites have garnered significant attention and hold promising prospects for bone repair applications. This paper provides a comprehensive insight into the properties of GO, preparation methods for nanocomposites, advantages of these materials, and relevant mechanisms for osteoporotic fracture applications.

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

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ROS Scavenging Graphene‐Based Hydrogel Enhances Type H Vessel Formation and Vascularized Bone Regeneration via ZEB1/Notch1 Mediation

Cited by 7 publications

References 65 publications

Mussel-Inspired Electroactive, Antibacterial and Antioxidative Composite Membranes with Incorporation of Gold Nanoparticles and Antibacterial Peptides for Enhancing Skin Wound Healing

Mussel-Inspired Electroactive, Antibacterial and Antioxidative Composite Membranes with Incorporation of Gold Nanoparticles and Antibacterial Peptides for Enhancing Skin Wound Healing

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

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