ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis

Zhao, Yanfang; Fan, Xiaopeng; Wang, Qimeng; Zhen, Junhui; Li, Xia; Zhou, Ping; Lang, Yating; Sheng, Qinghao; Zhang, Tingwei; Huang, Tingpei; Zhao, Yucheng; Lv, Zhimei; Wang, Rong

doi:10.1016/j.redox.2023.102674

Cited by 8 publications

(2 citation statements)

References 57 publications

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“…ROS attack-induced hydroxylation of methylcytidine generates 5hmC, which disrupts the accurate transmission of genomic methylation patterns ( 44 ). ROS facilitate the hypermethylation of NDRG2 promoters in a manner that is dependent on DNMTs, key enzymes in DNA methylation ( 45 ). Moreover, ROS can induce site-specific hypermethylation by upregulating DNMTs or forming new DNMT-containing complexes ( 43 ).…”

Section: Epigenetic Modification and Art-induced Cardiovascular Dysfu...mentioning

confidence: 99%

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Li,

Liu,

Huang

et al. 2024

Front. Cardiovasc. Med.

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Recently, the use of assisted reproductive technology (ART) has rapidly increased. As a result, an increasing number of people are concerned about the safety of offspring produced through ART. Moreover, emerging evidence suggests an increased risk of cardiovascular disease (CVD) in offspring conceived using ART. In this review, we discuss the epigenetic mechanisms involved in altered DNA methylation, histone modification, and microRNA expression, as well as imprinting disorders. We also summarize studies on cardiovascular changes and other risk factors for cardiovascular disease, such as adverse intrauterine environments, perinatal complications, and altered metabolism following assisted reproductive technology (ART). Finally, we emphasize the epigenetic mechanisms underlying the increased risk of CVD in offspring conceived through ART, which could contribute to the early diagnosis and prevention of CVD in the ART population.

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Section: Epigenetic Modification and Art-induced Cardiovascular Dysfu...mentioning

confidence: 99%

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Li,

Liu,

Huang

et al. 2024

Front. Cardiovasc. Med.

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“…Currently, MitoQ has been validated to delay age-related kidney fibrosis in a mouse aging model and improve vascular dysfunction in patients with chronic kidney failure, suggesting its potential for application in chronic kidney failure patients [189,190]. Mito-TEMPO, an SOD mimic composed of peroxynitrite and TPP coupling, effectively reversed DNA methylation and reduced kidney fibrotic changes in an NDRG2-dependent manner, leading to a notable enhancement in renal function in a rat model of chronic kidney failure [191,192]. Furthermore, mitochondrial-targeted quinone analogs such as SkQ1 and SkQR1, as well as the SOD mimic Mito-CP, have demonstrated renal protective effects in various acute kidney injury models, though their verification in chronic kidney failure models is still pending [193,194].…”

Section: "Stepping On the Brake"-targeting Mitochondrial Oxidative St...mentioning

confidence: 99%

Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

Wang,

Yang,

Zhang

et al. 2024

IJMS

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The function of the respiratory chain is closely associated with kidney function, and the dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney failure. The incidence of chronic kidney failure caused by defects in respiratory-chain-related genes has frequently been overlooked. Correcting abnormal metabolic reprogramming, rescuing the “toxic respiratory chain”, and targeting the clearance of mitochondrial reactive oxygen species are potential therapies for treating chronic kidney failure. These treatments have shown promising results in slowing fibrosis and inflammation progression and improving kidney function in various animal models of chronic kidney failure and patients with chronic kidney disease (CKD). The mitochondrial respiratory chain is a key target worthy of attention in the treatment of chronic kidney failure. This review integrated research related to the mitochondrial respiratory chain and chronic kidney failure, primarily elucidating the pathological status of the mitochondrial respiratory chain in chronic kidney failure and potential therapeutic drugs. It provided new ideas for the treatment of kidney failure and promoted the development of drugs targeting the mitochondrial respiratory chain.

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HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation

Li,

Ming,

Qin

et al. 2023

Advanced Science

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BRAF V600E attracts wide attention in the treatment of colorectal cancer (CRC) as stratifying and predicting a refractory classification of CRC. Recent evidence indicates that Wnt/β‐catenin signaling is broadly activated and participates in the refractoriness of BRAF V600E CRC, but the underlying molecular mechanism needs to be elucidated. Here, heat shock 70 kDa protein 8 (HSPA8), an essential regulator in chaperone‐mediated autophagy (CMA), is identified as a potential therapeutic target for advanced BRAF V600E CRC. These results show that HSPA8 is transcriptionally upregulated in BRAF V600E CRC, which promotes CMA‐dependent degradation of caveolin‐1 (CAV1) to release β‐catenin into the nucleus and thus activates the Wnt/β‐catenin pathway, contributing to metastasis and progression of BRAF V600E CRC. Of note, HSPA8 directly interacts with the KIFSN motif on CAV1, the interaction can be enhanced by p38 MAPK‐mediated CAV1 S168 phosphorylation. Furthermore, pharmacological targeting HSPA8 by VER155008 exhibits synergistic effects with BRAF inhibitors on CRC mouse models. In summary, these findings discover the important role of the HSPA8/CAV1/β‐catenin axis in the development of refractory BRAF V600E CRC and highlight HSPA8 as a predictive biomarker and therapeutic target in clinical practice.

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ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis

Cited by 8 publications

References 57 publications

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation

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