ROS-mediated MAPK activation aggravates hyperoxia-induced acute lung injury by promoting apoptosis of type II alveolar epithelial cells via the STAT3/miR-21–5p axis

Qin, Song; Liu, Jun-ya; Wang, Xiao-qin; Feng, Bang-hai; Ren, Ying-cong; Zheng, Jie; Yu, Kun; Yu, Hong; Li, Kang; Zhu, Feng; Chen, Miao; Fu, Xiaoyun; Chen, Tao; Xing, Zhou-xiong; Mei, Hong

doi:10.1016/j.molimm.2023.09.016

Molecular Immunology

2023

DOI: 10.1016/j.molimm.2023.09.016

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ROS-mediated MAPK activation aggravates hyperoxia-induced acute lung injury by promoting apoptosis of type II alveolar epithelial cells via the STAT3/miR-21–5p axis

Song Qin,

Jun-ya Liu,

Xiao-qin Wang

et al.

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2024

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MicroRNAs as Regulators of Radiation-Induced Oxidative Stress

Kura,

Pavelkova,

Kalocayova

et al. 2024

CIMB

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microRNAs (miRNAs) represent small RNA molecules involved in the regulation of gene expression. They are implicated in the regulation of diverse cellular processes ranging from cellular homeostasis to stress responses. Unintended irradiation of the cells and tissues, e.g., during medical uses, induces various pathological conditions, including oxidative stress. miRNAs may regulate the expression of transcription factors (e.g., nuclear factor erythroid 2 related factor 2 (Nrf2), nuclear factor kappa B (NF-κB), tumor suppressor protein p53) and other redox-sensitive genes (e.g., mitogen-activated protein kinase (MAPKs), sirtuins (SIRTs)), which trigger and modulate cellular redox signaling. During irradiation, miRNAs mainly act with reactive oxygen species (ROS) to regulate the cell fate. Depending on the pathway involved and the extent of oxidative stress, this may lead to cell survival or cell death. In the context of radiation-induced oxidative stress, miRNA-21 and miRNA-34a are among the best-studied miRNAs. miRNA-21 has been shown to directly target superoxide dismutase (SOD), or NF-κB, whereas miRNA-34a is a direct regulator of NADPH oxidase (NOX), SIRT1, or p53. Understanding the mechanisms underlying radiation-induced injury including the involvement of redox-responsive miRNAs may help to develop novel approaches for modulating the cellular response to radiation exposure.

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MicroRNAs as Regulators of Radiation-Induced Oxidative Stress

Kura,

Pavelkova,

Kalocayova

et al. 2024

CIMB

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ROS-mediated MAPK activation aggravates hyperoxia-induced acute lung injury by promoting apoptosis of type II alveolar epithelial cells via the STAT3/miR-21–5p axis

Cited by 1 publication

References 34 publications

MicroRNAs as Regulators of Radiation-Induced Oxidative Stress

MicroRNAs as Regulators of Radiation-Induced Oxidative Stress

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