ROS-induced translational regulation—through spatiotemporal differences in codon recognition—is a key driver of brown adipogenesis
Jun Yu Ip,
Indrik Wijaya,
Li Ting Lee
et al.
Abstract:The role of translational regulation in brown adipogenesis is relatively unknown. Localized translation of mRNAs encoding mitochondrial components enables swift mitochondrial responses, but whether this occurs during brown adipogenesis, which involves massive mitochondrial biogenesis, has not been explored. Here, we used ribosome profiling and RNA-Seq, coupled with cellular fractionation, to obtain spatiotemporal insights into translational regulation. During brown adipogenesis, a translation bias towards G/C-… Show more
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