ROS-Ca2+ is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis

Cao, Xiaohong; Zhao, Sisi; Liu, Dongyue; Wang, Zhuo; Niu, Lili; Hou, Lihua; Wang, Chunling

doi:10.1016/j.cbi.2011.01.010

Cited by 96 publications

(76 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…grisea hyphal cells (Fig. 5), which might lead to the release of mitochondrial intermembrane proteins into the cytoplasm, triggering cellular fragmentation and DNA damage and eventually causing cell apoptosis (24, 50). Collectively, the induction of ROS bursts by fengycin BS155 is suggested to contribute to cell death in M.…”

Section: Discussionmentioning

confidence: 99%

“…Surfactins were able to cause cell death of human breast cancer MCF-7 cells through the ROS/c-Jun N-terminal kinase-mediated mitochondrial/caspase pathway (23). Another study revealed that surfactins induce a collapse of mitochondrial membrane potential (MMP), initiating the release of cytochrome c from mitochondria and the activation of caspase 9, in MCF-7 cells (24). However, there are only few examples of investigations of the signaling pathways and intracellular cell responses to fengycins.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fengycins, Cyclic Lipopeptides from Marine Bacillus subtilis Strains, Kill the Plant-Pathogenic Fungus Magnaporthe grisea by Inducing Reactive Oxygen Species Production and Chromatin Condensation

Zhang

Sun

2018

Appl Environ Microbiol

165

123

View full text Add to dashboard Cite

Rice (Oryza sativa L.) is the most important crop and a primary food source for more than half of the world's population. Notably, scientists in China have developed several types of rice that can be grown in seawater, avoiding the use of precious freshwater resources and potentially creating enough food for 200 million people. The plant-affecting fungus Magnaporthe grisea is the causal agent of rice blast disease, and biological rather than chemical control of this threatening disease is highly desirable. In this work, we discovered fengycin BS155, a cyclic lipopeptide material produced by the marine bacterium Bacillus subtilis BS155, which showed strong activity against M. grisea. Our results elucidate the mechanism of fengycin BS155-mediated M. grisea growth inhibition and highlight the potential of B. subtilis BS155 as a biocontrol agent against M. grisea in rice cultivation under both fresh- and saltwater conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fengycins, Cyclic Lipopeptides from Marine Bacillus subtilis Strains, Kill the Plant-Pathogenic Fungus Magnaporthe grisea by Inducing Reactive Oxygen Species Production and Chromatin Condensation

Zhang

Sun

2018

Appl Environ Microbiol

165

123

View full text Add to dashboard Cite

show abstract

“…Cao et al, (2010) demonstrated that surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway. In a more recent work, they investigated the reactive oxygen species (ROS) and Ca 2+ impact on mitochondria permeability transition pore (MPTP) activity, and MCF-7 cell apoptosis induced by surfactin (Cao et al, 2011). The results showed that surfactin initially induced the ROS formation, leading to the MPTP opening accompanied with the collapse of mitochondrial membrane potential which lead to an increase in the cytoplasmic Ca 2+ concentration.…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Biosurfactants and Bioemulsifiers Biomedical and Related Applications – Present Status and Future Potentials

Fracchia¹,

Cavallo²,

Martinotti³

et al. 2012

Biomedical Science, Engineering and Technology

View full text Add to dashboard Cite

“…Opening of MPTP is mediated by high mitochondrial Ca 2þ concentrations and is facilitated by ROS [44]. Cross talk has been demonstrated between MPTP opening and mitochondrial ROS signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

The role of mitochondrial permeability transition pore in regulating the shedding of the platelet GPIbα ectodomain

Wang¹,

Cai²,

Hu³

et al. 2013

Platelets

View full text Add to dashboard Cite

Agonists induce platelet activation or apoptosis with concomitant shedding of the platelet receptor glycoprotein Ibα (GPIbα) ectodomain in a disintegrin and metalloproteinase 17 (ADAM17)-dependent mechanism. Mitochondrial permeability transition pore (MPTP) plays a pivotal role in platelet activation or apoptosis. However, its impact on ADAM17-mediated GPIbα ectodomain shedding remains unclear. Here, we aimed to test the hypothesis that MPTP regulates ADAM17-dependent GPIbα ectodomain shedding. We showed that calcium ionophore A23187- or thrombin plus collagen-induced GPIbα ectodomain shedding was partially inhibited by a MPTP inhibitor, and a MPTP potentiator promoted A23187-induced GPIbα cleavage. Furthermore, A23187-induced elevation of mitochondrial Ca(2+) levels was blocked by the mitochondrial calcium uniporter (MCU) inhibitor Ru360 or treatment with the membrane-permeable Ca(2+) chelator BAPTA-AM. We also demonstrated that an increase in mitochondrial Ca(2+) levels triggered MPTP opening, as revealed by the examination of mitochondrial inner transmembrane potential depolarization. In addition, A23187 induced-mitochondrial reactive oxygen species (ROS) generation was blocked by the MPTP inhibitor or by treatment with the mitochondria-targeted ROS scavenger. Lastly, A23187-induced GPIbα shedding was partially blocked by inhibitors of either ROS or calpain, and was completely inhibited when platelets were exposed to both inhibitors. Therefore, these observations indicate that MPTP opening triggered mitochondrial ROS production, which plays an important role in regulating ADAM17-mediated shedding of the GPIbα ectodomain in A23187-treated platelets.

show abstract

ROS-Ca2+ is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis

Cited by 96 publications

References 48 publications

Fengycins, Cyclic Lipopeptides from Marine Bacillus subtilis Strains, Kill the Plant-Pathogenic Fungus Magnaporthe grisea by Inducing Reactive Oxygen Species Production and Chromatin Condensation

Fengycins, Cyclic Lipopeptides from Marine Bacillus subtilis Strains, Kill the Plant-Pathogenic Fungus Magnaporthe grisea by Inducing Reactive Oxygen Species Production and Chromatin Condensation

Biosurfactants and Bioemulsifiers Biomedical and Related Applications – Present Status and Future Potentials

The role of mitochondrial permeability transition pore in regulating the shedding of the platelet GPIbα ectodomain

Contact Info

Product

Resources

About