Roridin H

Gai, Yue; Zhao, Lingling; Hu, Chang‐Qi; Zhang, Huiping

doi:10.1107/s1600536807024786

Cited by 2 publications

(1 citation statement)

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“…In 1999, the same group was able to employ insights from these X-ray studies in an investigation into the diastereomers of roridin E [ 110 ], following the work by Flippen-Anderson in 1986 [ 111 ], in order to infer the absolute configuration of various carbons in the sidechain, on the basis of 13 C NMR chemical shift differences near the stereogenic centers. The latest SCXRD work on the roridins was published by Gai in 2007 [ 112 ]. Here, the analysis of roridin H again focused on the stereochemistry of the sidechain, this time at positions C-4′, C-5′ and C-6′, which are part of a five-membered ring.…”

Section: Methods To Study Structurementioning

confidence: 99%

Current and Future Experimental Strategies for Structural Analysis of Trichothecene Mycotoxins—A Prospectus

Shank

Foroud

Hazendonk

et al. 2011

Toxins

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Fungal toxins, such as those produced by members of the order Hypocreales, have widespread effects on cereal crops, resulting in yield losses and the potential for severe disease and mortality in humans and livestock. Among the most toxic are the trichothecenes. Trichothecenes have various detrimental effects on eukaryotic cells including an interference with protein production and the disruption of nucleic acid synthesis. However, these toxins can have a wide range of toxicity depending on the system. Major differences in the phytotoxicity and cytotoxicity of these mycotoxins are observed for individual members of the class, and variations in toxicity are observed among different species for each individual compound. Furthermore, while diverse toxicological effects are observed throughout the whole cellular system upon trichothecene exposure, the mechanism of toxicity is not well understood. In order to comprehend how these toxins interact with the cell, we must first have an advanced understanding of their structure and dynamics. The structural analysis of trichothecenes was a subject of major interest in the 1980s, and primarily focused on crystallographic and solution-state Nuclear Magnetic Resonance (NMR) spectroscopic studies. Recent advances in structural determination through solution- and solid-state NMR, as well as computation based molecular modeling is leading to a resurgent interest in the structure of these and other mycotoxins, with the focus shifting in the direction of structural dynamics. The purpose of this work is to first provide a brief overview of the structural data available on trichothecenes and a characterization of the methods commonly employed to obtain such information. A summary of the current understanding of the relationship between structure and known function of these compounds is also presented. Finally, a prospectus on the application of new emerging structural methods on these and other related systems is discussed.

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Section: Methods To Study Structurementioning

confidence: 99%