ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma
Simone Benitz,
Alec Steep,
Malak M. Nasser
et al.
Abstract:Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions, to the progression of carcinoma subtypes associated with aggressiveness and therapeutic response. We discovered that normal acinar cell differentiation, maintained by the transcription factor Pdx1, suppresses a broad gastric cell identity that is maintained in metaplasia, neoplasia, and the classical subtype of PDAC in mouse and human. We have identified the recep… Show more
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