Ropivacaine: a new local anaesthetic agent in maxillofacial surgery

Budharapu, Abhishek; Sinha, Ramen; Uppada, Uday Kiran; Kumar, Anil

doi:10.1016/j.bjoms.2015.02.021

Cited by 34 publications

(28 citation statements)

References 18 publications

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“…The fact that local vasoconstriction can be obtained without the added epinephrine could be convenient in dentistry, as successful local anesthesia can be obtained in treating patients where it is not advisable to use epinephrine. Regarding the safety profile of ropivacaine, it has been indicated in this study that ropivacaine produces stable haemodynamic parameters in healthy patients, contrary to significant transient increase of HR evaluated after the injection of epinephrine (1:80.000) added to lidocaine anesthesia, what has been reported by Budharapu et al [24], recently. The haemodynamic response to epinephrine added to ropivacaine has already been a concern.…”

Section: Discussionmentioning

confidence: 54%

“…The existing information mainly refers to local anesthetic parameters obtained in volunteers [16][17][18][19][20], and limited data are available concerning the use of ropivacaine in dental practice [21][22][23]. There is a small note on the successful use of ropivacaine in a few oral surgical interventions, including extraction of impacted teeth [21,22,24], without mentioning the postoperative analgesia. Recently, we ascertained that maxillary infiltration of 0.75 and 1 % ropivacaine offers adequate and safe intraoperative analgesia, when used for upper third molar surgery [23].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study

et al. 2016

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study

et al. 2016

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“…It has been tested in dentistry with encouraging results about its duration of action 3 . In a recent randomized clinical trial, ropivacaine was compared with lignocaine hydrochloride for lower third molar extractions 4 . The primary objective of the present study was to compare the efficacy of 0.75% ropivacaine with 3% mepivacaine, one of the most common anesthetics used in dentistry, for pain control in the first 24 hours after surgery, using a quantitative measurement such as VAS; the secondary objective involved rescue analgesia.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Ropivacaine and Mepivacaine in the Postoperative Pain after Third Lower Molar Surgery

Crincoli¹,

Favia²,

Limongelli³

et al. 2015

Int. J. Med. Sci.

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Aim: To compare the efficacy of 0.75% ropivacaine with 3% mepivacaine for pain control in the first 24 hours after surgical removal of lower third molars, using a quantitative measurement such as VAS. The secondary objective involved rescue analgesia.Methods: Forty-five patients, 21 females and 24 males, mean age 23,2 ± 3 years, underwent surgical removal of third molars in two separate sessions. A split-mouth design was chosen, so each patient underwent both the first and second surgeries, having for each extraction a different anesthetic. The second extraction was carried out 1 month later. Parameters evaluated were: onset of anesthesia, duration of surgery, lip numbness, timing of pain appearance and first analgesic intake.Results: No significant differences about onset of anesthesia, duration of surgical procedures, and timing of first analgesic intake were found. Lower lip numbness, on the other hand, was more prolonged after using ropivacaine (p < 0.0001) and the onset of postoperative pain was more delayed after anesthesia with ropivacaine (p=0.0048). Pain scores at 1 and 2 hours after surgery were 3.5 ± 2.0 and 4.1 ±1.3 after injection of mepivacaine, and 2.7 ±2.2 and 2.9 ±2.4 after ropivacaine (p value =0.006 for both time points). No significant differences in pain score were recorded between the two anesthetics at 12 and 24 hours post surgery.Conclusions: With the use of ropivacaine, the discomfort caused by prolonged lip numbness is counterbalanced by less postoperative discomfort after surgery. In addition, when compared with other long-acting anesthetics, ropivacaine ensures a safer anesthetic profile for medically complex patients.

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“…The efficacy of local anesthesia depends on the concentration of ropivacaine applied: 0.25%, 0.5% or 0.75%. The average duration of local anesthesia after the application of ropivacaine is between 4-5 hours [11][12][13][14] . Prolonged action of local anesthetics is particularly required after major oral surgeries as a way of reducing the use of analgesics in the postoperative period.…”

Section: Introductionmentioning

confidence: 99%