Ropinirole suppresses LPS-induced periodontal inflammation by inhibiting the NAT10 in an ac4C-dependent manner
Haiqing Liao,
Huabing Ma,
Hongying Meng
et al.
Abstract:Background
Periodontitis is a chronic osteolytic inflammatory disease, where anti-inflammatory intervention is critical for restricting periodontal damage and regenerating alveolar bone. Ropinirole, a dopamine D2 receptor agonist, has previously shown therapeutic potential for periodontitis but the underlying mechanism is still unclear.
Methods
Human gingival fibroblasts (HGFs) treated with LPS were considered to mimic periodontitis in vitro. The d… Show more
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