ROP screening and treatment in four district-level special newborn care units in India: a cross-sectional study of screening and treatment rates

Sabherwal, Shalinder; Gilbert, Clare; Foster, Allen; Prabhash, Kumar

doi:10.1136/bmjpo-2020-000930

Cited by 4 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A secondary subanalysis was performed and found that there was a sex difference, with more male infants meeting the screening criteria for ROP than female infants (53% vs 47%). This is in contrast with previous data showing no sex differences among infants eligible for screening and those screened for ROP . In a recent large retrospective cohort study of 25 567 infants, Berrocal et al reported a high proportion of male patients (53%) screened for ROP, and this may reflect the higher percentage of male individuals requiring treatment.…”

Section: Discussionmentioning

confidence: 99%

The Male to Female Ratio in Treatment-Warranted Retinopathy of Prematurity

et al. 2022

View full text Add to dashboard Cite

ImportanceLiterature and anecdotal evidence suggest a relationship between male sex and retinopathy of prematurity (ROP). It is not known whether a difference, if present, is sex-related pathophysiologic predisposition or sex difference in meeting ROP screening criteria.ObjectiveTo evaluate the association of sex with the development of treatment-warranted ROP.Data SourcesPubMed, Embase, and Web of Science databases were searched from 2000 to 2022. The search strategy used keywords including retinopathy of prematurity or ROP or retrolental fibroplasia and treatment or anti-VEGF or bevacizumab or ranibizumab or aflibercept or conbercept or laser or cryotherapy and gender or sex or male or female and medical subject headings terms.Study SelectionAll studies reporting on treatment with anti–vascular endothelial growth factor, laser photocoagulation, and/or cryotherapy for ROP were identified. Studies reporting sex distribution in the treatment group were included in the meta-analysis. Exclusion criteria included case reports, case series of fewer than 10 treated patients, systematic reviews, conference abstracts, letters to the editor, animal studies, and non-English records.Data Extraction and SynthesisTwo reviewers independently screened and extracted the data following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The proportions of treated male and female infants were combined using random-effects meta-analysis.Main Outcomes and MeasuresNumbers and percentages of male and female infants treated for ROP.ResultsOf 11 368 identified studies, 316 met inclusion criteria, yielding a total of 31 026 treated patients. A higher percentage of male infants were treated for ROP (55% [95% CI, 0.54%-0.55%]), with low heterogeneity between studies (I2 = 34%; P &lt; .001). Thirty-eight studies reported sex distribution in the screened population (170 053 patients; 92 612 [53%] male vs 77 441 [47%] female). There was no significant difference in the odds of receiving treatment between screened male and female infants (pooled odds ratio, 1.04 [95% CI, 0.91-1.18]; P = .67).Conclusions and RelevanceMore male infants are treated for ROP than female infants. This could be due to a known relative pathophysiological fragility of preterm male infants in addition to a difference in ROP screening rates, with more male infants meeting the criteria than female infants. These findings have implications for future studies and may prompt more careful clinical monitoring of male neonates.

show abstract

Section: Discussionmentioning

confidence: 99%

The Male to Female Ratio in Treatment-Warranted Retinopathy of Prematurity

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, the adoption of these guidelines in clinical practice across India has not been optimal. 33 , 34 …”

Section: Learning From Gpeimentioning

confidence: 99%

“…Despite the existence of established guidelines and standards for ACS administration, oxygen administration and saturation targeting, and screening for ROP, adherence to these guidelines by healthcare providers remains suboptimal. 34 , 59 Effective measures are required to promote adherence to established guidelines for ROP management. Focusing on addressing attitudinal barriers among healthcare providers can facilitate the uptake of best practices in ROP management, ultimately improving patient outcomes.…”

Section: Prevention Of Ropmentioning

confidence: 99%

Retinopathy of prematurity in India – what can we learn from the polio legacy?

Athikarisamy

Vinekar

Patole

2023

The Lancet Regional Health - Southeast Asia

View full text Add to dashboard Cite

“…Sabherwal et al . [ 6 ] reported ROP in only 11% of those screened in four district-level SNCUs. In this study, only 18% of the eligible infants got screened, whereas only 56.5% of them completed screening.…”

mentioning

confidence: 99%