Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals

Pahuja, Monika; Mehla, Jogender; Reeta, K.H.; Joshi, Sujata; Gupta, Yogendra Kumar

doi:10.1016/j.eplepsyres.2011.09.006

Cited by 40 publications

(24 citation statements)

References 42 publications

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“…Root extracts are known to have antimicrobial, local anaesthetical, anti-depressive, insecticidal, and saliva stimulating features and are used to treat epilepsy, paralysis, toothache and rheumatism (Annalakshmi et al, 2012;Boonen et al, 2012b). Hydro-alcoholic and chloroform extracts of AP have anticonvulsive effects (Zaidi et al, 2009;Pahuja et al, 2012). In addition, aqueous extracts are used as aphrodisiac to improve the libido of men (Sharma et al, 2009).…”

Section: Introductionmentioning

confidence: 98%

Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract

et al. 2014

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Section: Introductionmentioning

confidence: 98%

Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract

et al. 2014

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“…In MES model, the extract produced a 16.7, 33.3, and 50% protection against THLE at doses of 250, 500, and 1000 mg/kg, respectively. Root extract also significantly prevented seizure-induced oxidative stress and cognitive impairment in a dose-dependent manner [12]. Recently Pahuja et al evaluated the effect of orally administration of hydroalcoholic extracts of A. pyrethrum root in the doses of 100, 250 and 500 mg/kg in the PTZ-induced kindling, spatial memory, oxidative stress, and rho kinase (ROCK II) in albino mice.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Iranian Traditional Medicine in the Treatment of Epilepsy

Fard

Shojaii

2013

BioMed Research International

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Epilepsy is a brain disorder which affects about 50 million people worldwide. Ineffectiveness of the drugs in some cases and the serious side effects and chronic toxicity of the antiepileptic drugs lead to use of herbal medicine as a form of complementary and alternative medicine. In this review modern evidences for the efficacy of antiepileptic medicinal plants in Traditional Iranian Medicine (TIM) will be discussed. For this purpose electronic databases including PubMed, Scopus, Sciencedirect, and Google Scholar were searched for each of the antiepileptic plants during 1970-February 2013.Anticonvulsant effect of some of the medicinal plants mentioned in TIM like Anacyclus pyrethrum, Pimpinella anisum, Nigella sativa, and Ferula gummosa was studied with different models of seizure. Also for some of these plants like Nigella sativa or Piper longum the active constituent responsible for antiepileptic effect was isolated and studied. For some of the herbal medicine used in TIM such as Pistacia lentiscus gum (Mastaki), Bryonia alba (Fashra), Ferula persica (Sakbinaj), Ecballium elaterium (Ghesa-al Hemar), and Alpinia officinarum (Kholanjan) there is no or not enough studies to confirm their effectiveness in epilepsy. It is suggested that an evaluation of the effects of these plants on different epileptic models should be performed.

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“…Earlier studies suggest that maximal electroshock and pentylenetetrazol might maintain their convulsive effects by inhibiting the activity of gamma amino butyric acid at GABA-A receptors (De Sarro et al, 1999;Vijayalakshmi et al, 2011). Pahuja et al (2012) and Zaidi et al (2009) had shown that A. pyrethrum extract has anti-epileptogenic effects on maximal electroshock and pentylenetetrazol models. This result is in agreement with the previously reported findings.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative potential of Anacyclus pyrethrum extract in generalized seizures in rat: Possible cholinergic mediated mechanism

Bezza

Gabbas

Laadraoui

et al. 2019

Bangladesh J Pharmacol

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The present study evaluates the anticonvulsant activity of the roots of Anacyclus pyrethrum using pilocarpine-induced experimental model of epilepsy in rat, and to determine its possible anticonvulsant mechanism. Ethanol extract (200 and 400 mg/kg) or alkylamides (25 and 50 mg/kg) was administered orally 45 min before the injection of pilocarpine-induced (400 mg/kg) seizures. The possible anticonvulsant mechanism was investigated by testing the effect of atropine (2 mL/kg) and scopolamine (1 mg/kg). The scoring of seizure severity, seizures time latency, duration of total seizures and percentage of mortality protection were recorded. Ethanol extract and alkylamides prolonged the time of onset seizure and decreased the duration of seizures compared to control group (p<0.001). The seizure protection was 100%. The co-administered of ethanol extract of A. pyrethrum and alkylamides with atropine completely abolished the pilocarpine-induced seizures. Video Clip of Methodology: Anticonvulsant effect: 6 min 7 sec: Full Screen Alternate

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Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals

Cited by 40 publications

References 42 publications

Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract

Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract

Efficacy of Iranian Traditional Medicine in the Treatment of Epilepsy

Ameliorative potential of Anacyclus pyrethrum extract in generalized seizures in rat: Possible cholinergic mediated mechanism

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