Root bark extracts of Myrianthus arboreus P. Beauv. (Cecropiaceae) exhibit anti-diabetic potential by modulating hepatocyte glucose homeostasis

Kasangana, Pierre Betu; Nachar, Abir; Eid, Hoda M.; Stevanović, Tatjana; Haddad, Pierre S.

doi:10.1016/j.jep.2017.09.017

Cited by 18 publications

(20 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following treatment with the aqueous extract of M. arboreus leaves, more than 66% of female rats were pregnant and 100% of gestational female rats had viable and healthy fetuses at birth. These results corrorate the observations previously made by Awounfack et al [30] in healthy animals and further support ethnobotanical data reporting the efficacy of M. arboreus in the treatment of female infertility [24,[28][29][30].…”

Section: Discussionsupporting

confidence: 90%

“…By increasing the production of estradiol, M. arboreus would have reduced oxidative stress in the ovaries of treated animals as evidenced by low levels of malondialdehyde (MDA, a lipid peroxidation byproduct and a marker of oxidative stress) and increased levels of antioxidant enzymes (catalase and total peroxidases), thus stimulating the resumption of follicular development and maturation, as shown by the increased number of Graafian follicles. This ability of M. arboreus to reduce oxidative stress in the ovaries of PCOS animals may be also attributed to its reported antioxidative properties [29,51,52].…”

Section: Discussionmentioning

confidence: 99%

“…(Cecropiaceae) for instance, commonly known as “kogom” in Bassa, “angokong” in Bulu and “lilanka” in Dschang, three Cameroonian vernacular languages, is a tree widely distributed in West, Central and East Africa where its young leaves are used for the treatment of various diseases, including diabetes [ 24 – 27 ]. The leaf aqueous extract of M. arboreus is used in Cameroon against amenorrhea, female infertility (primary and secondary) and to improve lactation [ 24 , 28 , 29 ]. Kasangana et al [ 29 ] reported that the root bark extracts of M. arboreus exhibits anti-diabetic potential in vitro.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The leaf aqueous extract of Myrianthus arboreus P. Beauv. (Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats

Mvondo

Tsoplfack

Awounfack

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background Myrianthus arboreus P. Beauv. (Cecropiaceae) is a medicinal plant used to treat female infertility. The aqueous extract of M. arboreus leaves was found to improve the fertility of healthy female Wistar rats. In the present study, we proposed evaluating the effects of such an extract on an animal model of infertility caused by polycystic ovary syndrome (PCOS), in order to bring scientific evidence to the curative action of this plant against female infertility. Methods Following a 21-day administration (gavage) of letrozole (1 mg/kg), animals with PCOS, indicated by overweight and an estrous cycle blocked in the diestrus phase, were co-treated with letrozole (1 mg/kg) and the aqueous extract of M. arboreus leaves at doses of 20, 110 and 200 mg/kg. The positive control received clomiphene citrate (1 mg/kg) and metformin (200 mg/kg). The negative control received distilled water. Each group of animals was made up of 10 female rats. Vaginal smear was examined 7 days before and during co-treatments. Co-treatments were orally administered for 30 consecutive days and 5 animals per group were sacrificed thereafter for biochemical and histological analyses. The 5 remaining animals in each group were crossbred with males of proven fertility for 5 consecutive days. The daily examination of vaginal smears allowed evaluating fertility index. Following parturition, gestation rate was calculated. Results The aqueous extract of M. arboreus leaves reversed letrozole effects by decreasing body weight, abdominal fat accumulation, and serum levels of LH and testosterone (p < 0.001). Ovarian dynamic was improved and the number of tertiary, Graafian follicles (p < 0.001) and corpus luteum increased while that of cystic (p < 0.001) and atretic follicles (p < 0.01) decreased. These effects were associated with increased serum levels of estradiol, decreased ovarian oxidative stress, the resumption of the estrous cycle, the hypertrophy of uterine epithelial cells and increased fertility index and gestation rate. Conclusions These results justify at least in part, the traditional use of M. arboreus against female infertility and suggest that this plant could be a promising alternative treatment to improve symptoms associated with different PCOS phenotypes.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The leaf aqueous extract of Myrianthus arboreus P. Beauv. (Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats

Mvondo

Tsoplfack

Awounfack

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

show abstract

“…Aqueous extracts of leaves are traditionally used in Cameroon against amenorrhea, female infertility (primary and secondary) and to improve lactation [ 25 , 31 ]. Studies published over the last decade revealed antioxidant [ 26 , 32 , 33 ], antibacterial [ 34 ], anti-infective and wound healing properties [ 28 ], hypoglycaemic and antihyperlipidaemic activities [ 35 ], and antidiabetic potential through cell-based bioassays [ 36 ] of this plant. In our previous study (safety evaluation), the oral administration of an aqueous extract of M. arboreus for 28 days in young adult (7–8 weeks old) Wistar rats increased ovarian and uterine wet weights, and the number of Graafian follicles and corpora lutea [ 37 ] suggesting the capacity to induce the production of sexual hormones, folliculogenesis and ovulation, and increase fertility index.…”

Section: Introductionmentioning

confidence: 99%

Myrianthus arboreus P. Beauv (Cecropiaceae) Extracts Accelerates Sexual Maturation, and Increases Fertility Index and Gestational Rate in Female Wistar Rats

et al. 2018

View full text Add to dashboard Cite

Background: Despite the wide use of leaves of Myrianthus arboreus (Cecropiaceae) in several African countries including Cameroon as food and against amenorrhea and female infertility, it has never been tested for this purpose. Methods: Using immature female Wistar rats, the impact of M. arboreus on the sexual maturation parameters (vaginal opening, ovarian relative weight and follicle maturation, gonadotropins and ovarian hormones serum levels) and fertility index has been evaluated through a 30-day oral administration of aqueous and methanol extracts of leaves at the doses of 20, 110 and 200 g/kg/day. Results: Aqueous extract increased the ovarian relative weight (p < 0.001), progesterone (p < 0.001) and gonadotropins (p < 0.001) serum levels, and induced the maturation of ovarian follicles. The methanol extract additionally induced an early vaginal opening (p < 0.001), uterine growth (p < 0.01) and increased estradiol (p < 0.001) serum levels. The fertility index generally increased following treatments, while the gestation rate remained almost unaffected except at the highest tested dose of M. arboreus extracts where lowest values were observed. Conclusion: Globally, M. arboreus induced an early puberty onset and an increased fertility rate validating at least in part its traditional use for female infertility.

show abstract

“…The spiritual and religious elements of Indigenous practice are interlinked and involve metaphysical forces and ancestors [9,11,12]. It follows then, that in addition to using medicinal herbs, many of which have proven efficacious by numerous studies [13][14][15][16][17][18][19], treatment can involve the use of resources drawn from the cosmic world [20]. Thus, African Indigenous medicine answers, not just the 'what' of illness but importantly, the 'why has this happened to me?'…”

Section: Introductionmentioning

confidence: 99%

The relationship between Indigenous and allopathic health practitioners in Africa and its implications for collaboration: a qualitative synthesis

Oseni

Shannon

2020

Global Health Action

View full text Add to dashboard Cite

Background: There have been increasing calls for collaboration between Indigenous health practitioners (IHPs) and allopathic health practitioners (AHPs) in Africa. Despite this, very few successful systems exist to facilitate formal collaboration. Direct relationships between providers, and at a health systems level are crucial to successful collaboration, but the nature and extent of these relationships have yet to be adequately explored. Objective: To explore the relationship between IHPs and AHPs in Africa, and to discuss the implications of this for future collaboration. Methods: An interpretive qualitative synthesis approach, combining elements of thematic analysis, meta-ethnography, and grounded theory, was used to systematically bring together findings of qualitative studies addressing the topic of collaboration between Indigenous and allopathic health practitioners in Africa. Results: A total of 1,765 papers were initially identified, 1,748 were excluded after abstract, full text and duplicate screening. Five additional studies were identified through references. Thus, 22 papers were included in the final analysis. We found that the relationship between Indigenous and allopathic health practitioners is defined by a power struggle which gives rise to lack of mutual understanding, rivalry, distrust, and disrespect. Conclusion: The power struggle which defines the relationship between IHPs and AHPs in Africa is a hindrance to their collaboration and as such could partly account for the limited success of efforts to foster collaboration to date. Future efforts to foster collaboration between IHPs and AHPs in Africa must aim to balance the power disparity between them if collaboration is to be successful. Since this would be a novel approach, decision-makers and organisations who trial this power balancing approach to facilitate collaboration should evaluate resultant policies and interventions to ascertain their feasibility and efficacy in fostering collaboration, and the lessons learnt should be shared.

show abstract

Root bark extracts of Myrianthus arboreus P. Beauv. (Cecropiaceae) exhibit anti-diabetic potential by modulating hepatocyte glucose homeostasis

Cited by 18 publications

References 34 publications

The leaf aqueous extract of Myrianthus arboreus P. Beauv. (Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats

The leaf aqueous extract of Myrianthus arboreus P. Beauv. (Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats

Myrianthus arboreus P. Beauv (Cecropiaceae) Extracts Accelerates Sexual Maturation, and Increases Fertility Index and Gestational Rate in Female Wistar Rats

The relationship between Indigenous and allopathic health practitioners in Africa and its implications for collaboration: a qualitative synthesis

Contact Info

Product

Resources

About