Room-temperature synthesis of core–shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

Guo, Lin; Gao, Chaohong; Zheng, Qi; Lei, Zhixian; Geng, Huijuan; Yang, Huanghao; Cai, Zongwei

doi:10.1039/c7cc00482f

Cited by 149 publications

(88 citation statements)

References 28 publications

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“…Furthermore, as another organic framework nanomaterials, the tentative application of COFs in proteomics also appeared. By taking advantage of inherent π–π stacking interaction and size‐exclusion effect of COFs, functionalized COFs exhibited effectively selective capture performance toward hydrophobic peptides . Additionally, molecular imprinting method has aroused great interest to fabricate tailor‐made affinity nanomaterials, which can extremely improve the selectivity of capturing the low‐abundance targets due to their rigid structures.…”

Section: Nanomaterials In Ordinary Proteomicsmentioning

confidence: 99%

Nanomaterials in Proteomics

Sun

Shen

et al. 2019

Adv Funct Materials

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For a deep understanding of the human proteome, the first crucial step is always the effective separation of targeted proteins/peptides from complex samples. In mass spectrometry‐based proteomics, nanomaterials have emerged as a highly effective means to separate targeted proteins/peptides and increase their relative abundance, which is beneficial to conduct mass spectrometric analysis. In particular, nanomaterials with different specific functionalities have received great attention in ordinary proteomics, phosphoproteomics, and glycoproteomics, for which the easily recognizable characteristics of these proteomes take the primary responsibility, such as the hydrophobicity, phosphate groups, cis–diol structure, and hydrophilicity. This review mainly focuses on the recent design and preparation of nanomaterials with specific recognition ability, as well as their application in the aforementioned three types of proteomics.

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Section: Nanomaterials In Ordinary Proteomicsmentioning

confidence: 99%

Nanomaterials in Proteomics

Sun

Shen

et al. 2019

Adv Funct Materials

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“…After the functionalization step,t he content descended from 7.94 to 2.43 mmol g À1 ,a nd this demonstrated that the aptamer was successfully graftedo nto Fe 3 O 4 @COF-COOH-15. [29] Sufficient magnetic properties are important for practical applicationso fm agnetic materials. 19-0629).…”

Section: Preparation and Characterization Of Fe 3 O 4 @Cof-aptmentioning

confidence: 99%

“…Moreover,c omparedw ith the spectrum of Fe 3 O 4 -15, the diffractionp eak that appeared ata bout 2.38 in that of Fe 3 O 4 @COF-Apt-15 might be due to the crystallinity of the COF shell. [29] Sufficient magnetic properties are important for practical applicationso fm agnetic materials. The magnetic properties of Fe 3 O 4 -15 and Fe 3 O 4 @COF-Apt-15 were determined by vibrating-sample magnetometry (VSM).…”

Section: Preparation and Characterization Of Fe 3 O 4 @Cof-aptmentioning

confidence: 99%

“…[25] Up to now,t he application of aptamer-functionalizedM OFs has been reported, which exhibit high adsorption capacity based on the specific affinity of aptamers towards targets. [29] Compared with MOFs, COFs exhibit higher structural stability,w hich makes them better candidates for applications in the field of separation. [29] Compared with MOFs, COFs exhibit higher structural stability,w hich makes them better candidates for applications in the field of separation.…”

Section: Introductionmentioning

confidence: 99%

“…[26][27][28] Thec oordination bonds betweenm etal ions and linkingo rganic ligandso fM OFs lead to their low chemical stabilityw hen they are exposed to organic solvents. [29] Compared with MOFs, COFs exhibit higher structural stability,w hich makes them better candidates for applications in the field of separation. However,a ptamer-functionalized COF materials remainundeveloped.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aptamer‐Functionalized Magnetic Conjugated Organic Framework for Selective Extraction of Traces of Hydroxylated Polychlorinated Biphenyls in Human Serum

Jiang

Zheng

et al. 2018

Chemistry A European J

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A solid-phase extraction adsorbent based on an aptamer-functionalized magnetic conjugated organic framework (COF) was developed for selective extraction of traces of hydroxylated polychlorinated biphenyls. This material has advantages such as superparamagnetism of the magnetic core, high surface area and porous structure of the COF, and high specific affinity of the aptamer. In combination with HPLC-MS, the aptamer-functionalized magnetic COF was used for the capture of hydroxy-2',3',4',5,5'-pentachlorobiphenyl in human serum. The method provided a linear range of 0.01-40 ng mL with a good correlation coefficient (R =0.9973). The limit of detection was as low as 2.1 pg mL . Furthermore, the material showed good reusability and could be applied in at least ten extraction cycles with recoveries greater than 90 %.

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Covalent Organic Frameworks: Structures, Synthesis, and Applications

Lohse

Bein

2018

Adv Funct Materials

981

706

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Covalent organic frameworks (COFs) are crystalline porous polymers formed by a bottom‐up approach from molecular building units having a predesigned geometry that are connected through covalent bonds. They offer positional control over their building blocks in two and three dimensions. This control enables the synthesis of rigid porous structures with a high regularity and the ability to fine‐tune the chemical and physical properties of the network. This Feature Article provides a comprehensive overview over the structures realized to date in the fast growing field of covalent organic framework development. Different synthesis strategies to meet diverse demands, such as high crystallinity, straightforward processability, or the formation of thin films are discussed. Furthermore, insights into the growing fields of COF applications, including gas storage and separations, sensing, electrochemical energy storage, and optoelectronics are provided.

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Room-temperature synthesis of core–shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

Cited by 149 publications

References 28 publications

Nanomaterials in Proteomics

Nanomaterials in Proteomics

Aptamer‐Functionalized Magnetic Conjugated Organic Framework for Selective Extraction of Traces of Hydroxylated Polychlorinated Biphenyls in Human Serum

Covalent Organic Frameworks: Structures, Synthesis, and Applications

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