Room temperature phosphorimetry of biologically-important compounds adsorbed on filter paper

Wellons, Stephen L.; Paynter, R. A.; Winefordner, J. D.

doi:10.1016/0584-8539(74)80063-2

Cited by 84 publications

(37 citation statements)

References 9 publications

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“…The observation of phosphorescence in the past was limited to rigid systems, especially those at liquid nitrogen temperatures (LTP) [1] or to analytes adsorbed on solid substrates (SS-RTP) [2]. A common aspect of phosphorimetry in fluid solution is the need for some form of molecular immobilization, protection, or both, to minimize non-radiative decay of luminophores, collisions with solvent, or the possibility of photochemical reaction.…”

Section: Introductionmentioning

confidence: 99%

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Díaz¹,

Terrones

Segura‐Carretero³

et al. 2004

Analytical and Bioanalytical Chemistry

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We present results from a comparative study of three proposed phosphorimetric methods for determination of naphazoline (NPZ) in solution. The first method is based on use of micelles to stabilize phosphorescence signals in solutions at room temperature (MS-RTP). The second is based on the use of a heavy atom salt and sodium sulfite as an oxygen scavenger to obtain room-temperature phosphorescence (HAI-RTP) in solution. The last method employs an optical sensor for NPZ based on the phosphorescent properties of the analyte on a solid sensor phase. The aim of this work was to compare time consumption, simplicity, sensitivity, selectivity, detection, and quantification limits for use of these three phosphorimetric methods to determine naphazoline in pharmaceutical preparations. The most simple, sensitive, and reproducible of the three methods for naphazoline analysis is the HAI-RTP method. Detection limits are 4.9, 1.7, and 9.4 ng mL(-1), respectively, for the MS-RTP, HAI-RTP, and optosensor methods.

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Section: Introductionmentioning

confidence: 99%

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Díaz¹,

Terrones

Segura‐Carretero³

et al. 2004

Analytical and Bioanalytical Chemistry

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“…In recent years the phenomenon of RTP has attracted large interest, and so also its application in spectroscopic analysis (Vo-Dinh 1984). In 1974, Winefordner and coworkers (Wellon et al 1974;Vo Dinh and Hooyhman 1979) established the general use of RTP as an analytical technique. Although many basic aspects of RTP remain to be explained, this phenomenon received immediate attention and rapidly found its place as a new spectrochemical technique for trace organic analysis.…”

Section: Introductionmentioning

confidence: 99%

Room-temperature phosphorescence of 2,2′-biquinoline in polymeric matrices

et al. 1993

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An original and very strong long-lived emission of 2,2'-biquinoline is observed in hydrogen-bonded polymeric matrices only. This long-lived emission (T o = 1 s) is ascribed to room-temperature phosphorescence (RTP) because of the large value of the decay time, the temperature-dependence, and the polarization results. The existence of hydrogen-bonded complexes in the ground state is assumed to be the origin of the RTP. They involve changes in the conformation of the 2,2'-biquinoline.

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“…Since its discovery in 1967 by Roth, 10 room temperature phosphorimetry (RTP) has attracted great interest and has become a practical technique for the detection of many organic compounds. [10][11][12][13][14][15][16][17][18] As the sample must be adsorbed on an inert substrate such as filter-paper, 19,20 the technique has the disadvantages of cumbersome sample preparation, critical drying requirements and high phosphorescent background intensity from the filter-paper substrate.…”

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confidence: 99%

Phosphorimetric Determination of Dipyridamole in Pharmaceutical Preparations

Pulgarı́n

Molina²,

López³

1997

Analyst

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Room temperature phosphorescence was applied to the determination of dipyridamole in pharmaceutical preparations. The response was linear in the concentration range 100-1600 ng ml-1. The use of phosphorescence enhancers such as thallium(I) nitrate (external heavy atom), sodium dodecyl sulfate (microemulsion stabilizer) and sodium sulfite (deoxygenation agent) was studied and optimized to obtain maximum sensitivity and adequate selectivity. The determination was performed in 0.026 M sodium dodecyl sulfate, 0.0156 M thallium nitrate and 0.02 M sodium sulfite. The pH value was 11.5, adjusted by adding sodium hydroxide. The phosphorescence was totally developed in 15 min, after that the intensity was measured at lambda ex = 303 nm and lambda em = 616 nm. The recovery of the method was tested on commercial formulations containing dipyridamole. The recoveries obtained were 94.67 +/- 0.58% for Persantin and 96.75 +/- 1.37% for Asasantin. The overall least squares regression method was applied to find the most exact straight line that fits the experimental data. The detection limit according to the error propagation theory was 16.4 ng ml-1. The repeatability and relative standard deviation were also determined according to this theory.

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Room temperature phosphorimetry of biologically-important compounds adsorbed on filter paper

Cited by 84 publications

References 9 publications

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations

Room-temperature phosphorescence of 2,2′-biquinoline in polymeric matrices

Phosphorimetric Determination of Dipyridamole in Pharmaceutical Preparations

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