Room-temperature controllable synthesis of hierarchically flower-like hollow covalent organic frameworks for brain natriuretic peptide enrichment

Abstract

A facile strategy was introduced for room-temperature controllable synthesis of hierarchically flower-like hollow COFs (FHF-COFs). Furthermore, the universality for synthesis of the HFH-COFs was validated by altering building units. Inspired...

Emerging porous organic polymers for biomedical applications

“…Then, a brief discussion on their synthetic strategies and functionalization approaches is provided. Subsequently, a detailed description is provided on the applications of POPs in diverse biomedical fields, including drug delivery, 76,101–116 biomacromolecule encapsulation, 117–129 photodynamic and photothermal therapy, 130–147 biosensing, 69,148–151 bioimaging, 152–155 antibacterial, 156–161 bioseparation, 162 and others, as shown in Fig. 2.…”

Hydrophilic glutathione-modified flower-like hollow covalent organic frameworks for highly efficient capture of N-linked glycopeptides

“…It is worth mentioning that the inherent chemical and thermal stability and large surface area of the HFH-COFs made it an appropriate substrate to load a high amount of Au NPs and it was subsequently modified with a large number of hydrophilic GSH. 31 As shown in Scheme 1(B), the obtained HFH-COFs@Au@GSH had potential as a hydrophilic and biocompatible adsorbent and can be used as an efficient probe for N -glycopeptide enrichment.…”

“…Herein, glutathione (GSH)-modified hierarchical flower-like hollow covalent organic frameworks loaded with Au nanoparticles (HFH-COFs@Au@GSH) were successfully synthesized for N-glycopeptide enrichment. The hierarchical flower-like hollow structure was reported to exhibit a large specific surface area and high metal solid loading, [31][32][33] which was expected to load a large amount of Au NPs and subsequent hydrophilic GSH. The properties of the HFH-COFs@Au@GSH including high specific surface area and strong hydrophilicity were characterized via different techniques.…”

Phosphorylation of covalent organic framework nanospheres for inhibition of amyloid-β peptide fibrillation

“…In brief, TPB and DHTP in the molar ratio of 2 : 3 were added to acetonitrile (ACN) containing acetic acid (HAc, 0.7 mL, 12 M). 32,44,45 Aer the solution stood at room temperature for 12 h, a yellow precipitate was obtained. The collected precipitate was rinsed with MeOH and then activated in a vacuum, which gave the preliminary product (TD-COFs).…”