This chapter examines the contribution of the contextual study of human skeletal remains of Early Christian burials in the eastern Mediterranean. Bioarchaeological studies of sites in Greece, Cyprus, Asia Minor, and Palestine are presented to better understand the people and their burial practices from this region during a tumultuous period in the fourth through seventh centuries. The use of multiple lines of evidence such as funerary archaeology, taphonomy, and skeletal biology reveals the lifestyles and burial customs of the inhabitants from a selection of eastern Mediterranean sites. Despite regional variations, there is a great degree of uniformity in the burial customs across the areas under consideration. Finally, the populations of the eastern Mediterranean share similar demographic profiles and health outcomes. Future research will likely engage in scientific applications in archaeology that may address significant questions, such as reconstructing diet from stable isotope analyses and disease via ancient DNA analysis.