Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study

Pallayová, Mária; Brenišin, Marek; Putrya, Alina; Vrsko, Martin; Dražilová, Sylvia; Janíčko, Martin; Mareková, Mária; Pella, Daniel; Gecková, Andrea Madarasová; Urdzík, Peter; Jarčuška, Peter; Team, HepaMeta

doi:10.3390/ijerph17207673

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…However, no independent correlation was shown between UA and the risk of NAFLD after adjusting for confounding factors, which suggested that the effect of UA may not be direct but indirect through other risk factors for NAFLD ( 44 ). This study showed that UA levels were correlated with serum ferritin, and the mechanism may be via inflammation induced by UA through the p38 mitogen-activated protein kinase, cyclooxygenase-2, and chemokine cyto-chemotactic protein-1 signal pathway ( 45 ).…”

Section: Discussionmentioning

confidence: 91%

Serum ferritin is correlated with non-alcoholic fatty liver disease in middle-aged and older patients with type 2 diabetes

Yan

Pan

Zhao

et al. 2021

Endocrine Connections

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Objective Previous studies have shown the correlations between serum ferritin and non-alcoholic fatty liver disease (NAFLD) or diabetes. However, this relationship remains unclear in patients with type 2 diabetes (T2DM) with NAFLD. Therefore, this study aimed to elaborate the relationship between serum ferritin levels and NAFLD in middle-aged and older patients with T2DM and further explored the biomarkers for NAFLD in T2DM. Methods A total of 805 middle-aged and older patients with T2DM were divided into NAFLD and non-NAFLD groups, and their serum ferritin levels were compared. Next, NAFLD group were divided into five subgroups according to the quintile levels of serum ferritin, and the differences in the constituent ratios of NAFLD were analyzed. A logistic regression analysis was performed to determine the risk factors for NAFLD in patients with T2DM. Results The serum ferritin levels were significantly higher in T2DM patients with NAFLD (168.47 (103.78, 248.00) ng/mL) than in the non-NAFLD patients (121.19 (76.97, 208.39) ng/mL). The constituent ratios of NAFLD were significantly higher in the F5 and F4 groups than in the F2 or F1 groups (22.70 and 22.70% vs. 15.90 and 16.90%, respectively; P < 0.05). Binary logistic regression analysis showed that serum ferritin (P = 0.001) was an independent risk factor for NAFLD in patients with T2DM. Conclusions Serum ferritin levels were significantly increased in T2DM with NAFLD, and the constituent ratios of NAFLD increased gradually along with the increased levels of serum ferritin. Thus, serum ferritin is an independent risk factor for NAFLD in patients with T2DM.

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Section: Discussionmentioning

confidence: 91%

Serum ferritin is correlated with non-alcoholic fatty liver disease in middle-aged and older patients with type 2 diabetes

Yan

Pan

Zhao

et al. 2021

Endocrine Connections

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“…Recently, research of Roma health has focused on chronic illness and risk factors as determinants of mortality. Recent evidence suggests that the Roma population is at increased cardiovascular and metabolic risk and highlights the need for further investigations on the prevalence of cardiovascular risk factors among Roma people that would facilitate the diagnosis and would help to the development of effective strategies for CVD prevention among Roma population (6,24).…”

Section: Discussionmentioning

confidence: 99%

Assessment of health status and cardiovascular risk factors in a Roma population sample from South Bulgaria

Delcheva¹,

Stankova²,

Stefanova³

et al. 2023

Cent Eur J Public Health

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Objectives: Roma population is one of the major ethnic groups in the Central and Eastern Europe, having high rates of chronic diseases and associated risk factors related to their poor social conditions, unhealthy lifestyle and low educational level. The purpose of our study was to assess the health status of Roma from South Bulgaria by means of blood indicators and determine the prevalence of some cardiovascular (CV) risk factors in the Roma population sample.Methods: The study group consisted of 60 Roma (23 men and 37 women), mean age 53.7 ± 15.9 years, and the control group consisted of 68 non-Roma from the majority population (29 men and 38 women), mean age 45.8 ± 12.2 years. The data were collected via questionnaire, anthropometric measures, and venous blood samples analyses after an overnight fasting.Results: The Roma population subjects were slightly but significantly older compared to the non-Roma group and both study groups included more women. The fasting glucose, body mass index (BMI), triglycerides (TG), total cholesterol (TC), and LDL-cholesterol (LDL-C) levels were significantly higher, and HDL-cholesterol (HDL-C) levels were significantly lower in Roma compared to the control non-Roma group. The values of cardiovascular risk markers such as TC/HDL-C and TG/HDL-C ratios, atherogenic index of plasma (AIP) and lipoprotein combine index (LCI) were significantly higher in Roma compared to non-Roma subjects. The prevalence of obesity in Roma was 35%, diabetes mellitus was recorded in 16.7% of the entire Roma sample, and hyperglycaemia in non-diabetics was recorded in 32%. Hypercholesterolaemia was found in 90% and hypertriglyceridaemia was found in 88.3%. The prevalence of cardiovascular diseases (CVD) was high and was encountered in 71.7% of the Roma participants and most of the subjects (96.7%) reported family history of CVD. The studied population showed high smoking rates with 33.3% active smokers.Conclusions: Our study confirmed high prevalence of CV risk factors among Roma population, such as abnormal lipid profile parameters, obesity and heavy smoking and very high cardiovascular morbidity rate. Therefore, adequate measures and healthcare programmes aiming at the early identification, treatment and prevention of CVD risks among Roma are necessary.

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“…One animal study revealed that estrogen in the mouse model may regulate the expression or activity of UA transporters, specifically ABCG2 and SLC2A9, and this regulation increases UA excretion via renal proximal tubules and even small intestines [12]. The HepaMeta Study demonstrated that SUA level is related to gender, and higher SUA was noted in Roma males than in females, accompanied by elevated CRP and serum ferritin, as a marker of cardiovascular risk [13]. They pinpointed that females benefited from estrogen itself to prevent hyperuricemia and even gouty attack.…”

Section: Discussionmentioning

confidence: 99%

Reduced Incidence of Stroke in Patients with Gout Using Benzbromarone

Niu

Hung

Lin

et al. 2022

JPM

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Gout is strongly associated with the incidence of atherosclerotic events, including stroke and myocardial infarction. Considering the increased prevalence of stroke in the population with gout, the aim of this study was to evaluate the effects of benzbromarone, a uricosuric agent, on the incidence of stroke in the population with gout. We used data from the Taiwanese National Health Insurance Registration Database (NHIRD). The benzbromarone user cohort included 15,143 patients; each patient was age- and sex-matched with one non-user randomly selected from the population with gout. Cox proportional hazard regression analysis was conducted to estimate the effects of benzbromarone on the incidence of stroke in the population with gout. The incidence of stroke was significantly lower in benzbromarone users than in benzbromarone non-users. The HR for the incidence of stroke was lower in male benzbromarone users than in non-users. An analysis of three age groups (<40, 40–59, and ≥60 years) indicated that the HRs in those aged 40–59 years and ≥60 years were significantly lower among benzbromarone users than non-users. In the population with gout, the incidence of stroke was lower in benzbromarone users than in benzbromarone non-users.

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Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study

Cited by 8 publications

References 42 publications

Serum ferritin is correlated with non-alcoholic fatty liver disease in middle-aged and older patients with type 2 diabetes

Serum ferritin is correlated with non-alcoholic fatty liver disease in middle-aged and older patients with type 2 diabetes

Assessment of health status and cardiovascular risk factors in a Roma population sample from South Bulgaria

Reduced Incidence of Stroke in Patients with Gout Using Benzbromarone

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