Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data

Roll compaction process modeling: Transfer between equipment and impact of process parameters

“…Over the past few decades, several researchers have attempted to model roll compaction process (Bindhumadhavan et al, 2005;Dec, 1991;Johanson, 1965;Katashinskii, 1966Nesarikar et al, 2012aPatel et al, 2010;Reynolds et al, 2010). Johanson (1965) initiated this work by developing a powder mechanics model that enabled the roll surface pressure, torque and separating force of the rolls to be predicted from the physical characteristics of the powder and the dimensions of the rolls.…”

“…Furthermore, Nesarikar et al (2012a) developed an approach using roll force equation based on a modified Johanson model in which the requirement of pressure value at nip angle was eliminated. The model is capable of providing ribbon density as a function of gap and RFU (roll force per unit roll width) allowing to scale up from the Alexanderwerk WP120 to WP200 unit.…”

“…Generally, modern tablet presses are equipped with real-time compression force measurements that can be used to obtain the desired relative density of tablets during process scale up or transfer. This is normally not the case for a roll compactor where such pressure sensors do not come standard with the equipment, making scale up of roll compactor process more challenging (Nesarikar et al, 2012a).…”

An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms

“…The most important models are Johnson's model as well as finite element methods. Artificial neural networks and genetic algorithms have been used as well [80][81][82][83][84][85].…”

Mechanistic Insights into the Scale‐Up of the Roller Compaction Process: A Practical and Dimensionless Approach

“…Solid fractions (experimental data = points, model = line) of ribbons prepared by roller compaction, as a function of a modified Bingham number, B m *: (a) ribbons manufactured using an A lexanderwerk® WP 120 roller compactor and (b) comparison of placebo ribbons prepared on an A lexanderwerk® WP 120 and A lexanderwerk® WP 200. Experimental A lexanderwerk® WP 200 data adapted from N esarikar et al…”