Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model
Rafael Martinez-Carrasco,
Satyanarayan Rachagani,
Surinder K. Batra
et al.
Abstract:Membrane-associated mucins (MAMs) are proposed to play critical roles at the ocular surface; however, in vivo evidence has been lacking. Here we investigate these roles by phenotyping of a Muc4 KO mouse. Histochemical analysis for expression of the beta-galactosidase transgene replacing Muc4 revealed a spiraling ribbon pattern across the corneal epithelium, consistent with centripetal cell migration from the limbus. Depletion of Muc4 compromised transcellular barrier function, as evidenced by an increase in ro… Show more
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