Roles of volume‐activated Cl⁻ currents and regulatory volume decrease in the cell cycle and proliferation in nasopharyngeal carcinoma cells

Abstract

Activity of the volume-activated chloride channel is one of the important factors that regulate the passage of cells through the G1 restriction point and that the Cl- current associated with RVD plays an important role in cell proliferation.

Physiology of Cell Volume Regulation in Vertebrates

“…Also ClC-3 expression varies through the cell cycle (1065), and ClC-3 deficiency prevents proliferation of rat aortic smooth muscle cells (1063). Finally, in nasopharyngeal carcinoma cells, I Cl,vol activity was found to be important in control of passage through the G 1 restriction point (124). For a recent review on the roles of cell volume regulatory ion channels in control of proliferation, see Reference 511.…”

Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance

“…[60][61][62] In particular, changes in VRAC activity seem important for the G 1 /S transition phase and many cells are halted in the G 1 phase by Cl -channel inhibitors. [63][64][65][66][67][68][69] It should be noted that conclusions about VRAC and cell cycle generally rely on data obtained with pharmacological compounds with low selectivity / specificity and should be reinvestigated now that essential components of VRAC have been cloned. 2,4 In ELA cells patch clamp experiments revealed that VRAC activity decreased as ELA cells go from G 0 to G 1 , and increased again when they go from G 1 to S 66 ( Fig.…”

ClC-3 is a candidate of the channel proteins mediating acid-activated chloride currents in nasopharyngeal carcinoma cells

“…Acid-induced channels may be involved in tumor growth by mediation of the chloride currents activated by acidity. It was demonstrated by us previously that chloride channels are associated with the regulation of the cell cycle, cell proliferation, and migration in nasopharyngeal carcinoma cells (4,17). The roles of the acid-activated chloride currents in regulation of these cell functions need to be clarified in future studies.…”