Roles of various cullin-RING E3 ligases involved in hormonal and stress responses in plants

Seo, Kyoung‐In; Song, Eun-Young; Chung, Sunglan; Lee, Jae‐Hoon

doi:10.1007/s12374-012-0902-4

Cited by 11 publications

(6 citation statements)

References 82 publications

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“…The first group is composed of Really Interesting New Gene (RING)/U-box and Homology to E6-AP Carboxyl Terminus E3s, which act as a single subunit (Dreher and Callis, 2007;Vierstra, 2009;Yee and Goring, 2009). The second group is composed of multisubunit Ub ligases, including the Skp1-Cullin-F-box complex and the anaphase-promoting complex (Vierstra, 2009;Park et al, 2011;Sadanandom et al, 2012;Seo et al, 2012b). In the Arabidopsis (Arabidopsis thaliana) genome, at least 477 genes encode putative RING E3 Ub ligases; thus, these ligases are the most abundant E3s among single subunittype Ub ligases and the third largest gene family in Arabidopsis Stone et al, 2005;Vierstra, 2009).…”

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confidence: 99%

The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP3/LOG2 Participates in Positive Regulation of High-Salt and Drought Stress Responses

Kim

2013

Plant Physiology

125

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Really Interesting New Gene (RING) E3 ubiquitin ligases have been implicated in cellular responses to the stress hormone abscisic acid (ABA) as well as to environmental stresses in higher plants. Here, an ABA-insensitive RING protein3 (atairp3) loss-of-function mutant line in Arabidopsis (Arabidopsis thaliana) was isolated due to its hyposensitivity to ABA during its germination stage as compared with wildtype plants. AtAIRP3 contains a single C3HC4-type RING motif, a putative myristoylation site, and a domain associated with RING2 (DAR2) domain. Unexpectedly, AtAIRP3 was identified as LOSS OF GDU2 (LOG2), which was recently shown to participate in an amino acid export system via interaction with GLUTAMINE DUMPER1. Thus, AtAIRP3 was renamed as AtAIRP3/LOG2. Transcript levels of AtAIRP3/LOG2 were up-regulated by drought, high salinity, and ABA, suggesting a role for this factor in abiotic stress responses. The atairp3/log2-2 knockout mutant and 35S:AtAIRP3-RNAi knockdown transgenic plants displayed impaired ABAmediated seed germination and stomata closure. Cosuppression and complementation studies further supported a positive role for AtAIRP3/LOG2 in ABA responses. Suppression of AtAIRP3/LOG2 resulted in marked hypersensitive phenotypes toward high salinity and water deficit relative to wild-type plants. These results suggest that Arabidopsis RING E3 AtAIRP3/LOG2 is a positive regulator of the ABA-mediated drought and salt stress tolerance mechanism. Using yeast (Saccharomyces cerevisiae) two-hybrid, in vitro, and in vivo immunoprecipitation, cell-free protein degradation, and in vitro ubiquitination assays, RESPONSIVE TO DEHYDRATION21 was identified as a substrate protein of AtAIRP3/LOG2. Collectively, our data suggest that AtAIRP3/LOG2 plays dual functions in ABA-mediated drought stress responses and in an amino acid export pathway in Arabidopsis.

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confidence: 99%

The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP3/LOG2 Participates in Positive Regulation of High-Salt and Drought Stress Responses

Kim

2013

Plant Physiology

125

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“…Ubiquitin plays important roles in maintaining cellular homeostasis and enables effective adaptation to environmental changes. Seo et al reported that the role of ubiquitination was associated with hormonal signaling [ 42 ]. Therefore, the maternal-ELD gene GRMZM2G063931 may regulate plant response to abiotic stress through hormone abscisic acid mediated by ubiquitination in Zhengdan958.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study on the Transcriptome of Maize Mature Embryos from Two China Elite Hybrids Zhengdan958 and Anyu5

Cao

et al. 2016

PLoS ONE

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Zhengdan958 and Anyu5 are two elite maize hybrids of China, which manifest similar paternal lines (Chang7-2) but different maternal lines (Zheng58 and Ye478). Zhengdan958 has a 10–15% yield advantage over Anyu5. In this study, we applied digital gene expression technology to analyze transcriptomes of mature embryos from the two hybrids and their parents, aimed to investigate molecular mechanism of heterosis and genetic effects of maternal lines. Results showed that 71.66% and 49.70% of differentially expressed genes exhibited non-additive expression in Zhengdan958 and Anyu5, respectively. The number of non-additive genes involved in abiotic and biotic stress responses in Zhengdan958 was higher than that in Anyu5, which was in agreement with their phenotypic performance. Furthermore, common over-dominance and under-dominance genes (137 and 162, respectively) between the two hybrids focused on plant development and abiotic stress response. Zhengdan958 contained 97 maternal expression-level dominance (maternal-ELD) genes, and the number was higher than that of Anyu5 (45). Common up-regulated maternal-ELD genes were significantly enriched in meristem and shoot development while common down-regulated maternal-ELD genes were involved in pyruvate metabolic process, negative regulation of catalytic activity and response to stress. Therefore, non-additive genes mainly contribute to heterosis in Zhengdan958, including many genes for plant development, abiotic and biotic stress responses. Maternal effects may play important roles in maize heterosis.

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“…In plant hormone signalling, ubiquitination either targets TFs or their repressors via proteasomal degradation [94][95][96][97]. Less is known about the E3 ligases involved in nutrient signalling.…”

Section: The Ubiquitination Machinery Allows For Further Signal Diver...mentioning

confidence: 99%

“…Combinatorial substitutions allow for components to act in multiple pathways Allows for variations in UPS response across tissues and throughout development [60,85,94,95,[101][102][103][104]135] CSN activity Neddylation/deneddylation CSN activity CAND1 activity Addition of NEDD8 for decreased CRL complex affinity and interchange of SCF Steric obstruction of CSN by TS inhibits deneddylation and promotes TS ubiquitination CAND1 mediated FBX exchange 'shuffles' FBX/ASK in the absence of TS [117][118][119][120]122,134] ABA, abscisic acid; ASK, ARABIDOPSIS SKP1-LIKE protein; BR, brassinosteriod; CAND1, CULLIN-ASSOCIATED AND NEDDYLATION-DISSOCIATED1; CRL, CULLIN-RING E3 ligase complex; CSN, COP9 signalosome; FBX, F-box protein; GA, gibberellic acid; IAA, indole-3-acetic acid/auxin; JA-Ile, jasmonic acid-isoleucine conjugate; SA, salicylic acid; SCF, SKP1-CULLIN-FBX PROTEIN complex; TS, target substrate; TF, transcription factor; UBC, E2 conjugating enzyme.…”

Section: Ubc E3 Ligase Scf Complex Affinitymentioning

confidence: 99%

Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level

Collins,

Shou,

Mao

et al. 2024

Biochemical Journal

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The plant macronutrient phosphorus is a scarce resource and plant-available phosphate is limiting in most soil types. Generally, a gene regulatory module called the phosphate starvation response (PSR) enables efficient phosphate acquisition by roots and translocation to other organs. Plants growing on moderate to nutrient-rich soils need to co-ordinate availability of different nutrients and repress the highly efficient PSR to adjust phosphate acquisition to the availability of other macro- and micronutrients, and in particular nitrogen. PSR repression is mediated by a small family of single SYG1/Pho81/XPR1 (SPX) domain proteins. The SPX domain binds higher order inositol pyrophosphates that signal cellular phosphorus status and modulate SPX protein interaction with PHOSPHATE STARVATION RESPONSE1 (PHR1), the central transcriptional regulator of PSR. Sequestration by SPX repressors restricts PHR1 access to PSR gene promoters. Here we focus on SPX4 that primarily acts in shoots and sequesters many transcription factors other than PHR1 in the cytosol to control processes beyond the classical PSR, such as nitrate, auxin, and jasmonic acid signalling. Unlike SPX1 and SPX2, SPX4 is subject to proteasomal degradation not only by singular E3 ligases, but also by SCF–CRL complexes. Emerging models for these different layers of control and their consequences for plant acclimation to the environment will be discussed.

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Roles of various cullin-RING E3 ligases involved in hormonal and stress responses in plants

Cited by 11 publications

References 82 publications

The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP3/LOG2 Participates in Positive Regulation of High-Salt and Drought Stress Responses

The Arabidopsis RING E3 Ubiquitin Ligase AtAIRP3/LOG2 Participates in Positive Regulation of High-Salt and Drought Stress Responses

Comparative Study on the Transcriptome of Maize Mature Embryos from Two China Elite Hybrids Zhengdan958 and Anyu5

Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level

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