Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications

Yan, M. F.; Zheng, Minying; Niu, Rui; Yang, Xiaohui; Tian, Shifeng; Fan, Linlin; Li, Yuwei

doi:10.3389/fcell.2022.938289

Cited by 22 publications

(14 citation statements)

References 135 publications

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“…Systemic inflammatory reflection has been well confirmed to be closely associated with the occurrence and progression of malignancies ( 5 ). Increased neutrophils and monocytes in the tumor microenvironment have been reported to induce myeloid-derived suppressor cells, thereby suppressing the host immunity and prompting the tumor growth ( 30 , 31 ). In addition, monocytes can differentiate into tumor-associated macrophages, which is associated with creating a favorable microenvironment for cancer development ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of pan-immune-inflammation value in colorectal cancer patients: A systematic review and meta-analysis

Yang

Liu

et al. 2022

Front. Oncol.

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BackgroundThe pan-immune-inflammation value (PIV) has been reported as a novel prognostic biomarker in multiple malignancies. The aim of this study is to investigate the prognostic value of the PIV in patients with colorectal cancer.MethodsWe comprehensively searched electronic databases including PubMed, Embase and Web of Science up to August 2022. The endpoints were survival outcomes. Hazard ratios (HRs) with 95% confidence intervals (CIs) for survival data were collected for analysis.ResultsSix studies including 1879 participants were included. A significant heterogeneity in the PIV cut-off value among studies was observed. The combined results indicated that patients in the high baseline PIV group had a worse overall survival (HR=2.09; 95%CI: 1.67-2.61; P<0.0001; I2 = 7%) and progression-free survival (HR=1.82; 95%CI: 1.49-2.22; P<0.0001; I2 = 15%). In addition, early PIV increase after treatment initiation was significantly associated with decreased overall survival (HR=1.79; 95%CI: 1.13-2.93; P=0.01; I2 = 26%), and a trend toward poor progression-free survival (HR=2.00; 95%CI: 0.90-4.41; P=0.09; I2 = 70%).ConclusionBased on existing evidence, the PIV could act as a valuable prognostic index in patients with colorectal cancer. However, the heterogeneity in the PIV cut-off value among studies should be considered when interpreting these findings.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of pan-immune-inflammation value in colorectal cancer patients: A systematic review and meta-analysis

Yang

Liu

et al. 2022

Front. Oncol.

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Section: Methodsmentioning

confidence: 99%

“…The triggered inflammatory response is characterized by an increase in the neutrophil population that mediates a pro-carcinogenic effect, by promoting angiogenesis, cancer cell migration, with local invasion and metastasis. 36,37 In addition, neutrophils indirectly regulate the epithelialmesenchymal transition, through the production of oncogenic cytokines and chemokines, such as interleukins (IL)-1β, IL-6, IL-12, and TNF-α, which promote the recruitment and further activation of other inflammatory cells. [38][39][40][41] However, in the leukocyte infiltrate, monocytes predominate, which, through metamorphosis, become macrophages.…”

Section: The Relationship Between the Chronic Inflammatory Process An...mentioning

confidence: 99%

Systemic inflammation factors as survival prognosis markers in ovarian neoplasm and the relationship with cancer-associated inflammatory mediators—a review

Dinca

Diaconu

Bîrlă

et al. 2023

Int J Immunopathol Pharmacol

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At the level of the genital system, ovarian neoplasm is the most frequent cause of morbidity and mortality. In the specialized literature, the coexistence of an inflammatory process is admitted from the early stages of the evolution of this pathology. Starting from the importance of this process, both in determinism and in the evolution of carcinogenesis and summarizing the field of knowledge, for this study we considered two objectives: the first was the presentation of the pathogenic mechanism, through which chronic +ovarian inflammation is involved in the process of carcinogenesis, and the second is the justification of the clinical utility of the three parameters, accepted as biomarkers of systemic inflammation: neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and lymphocyte-monocyte ratio in the assessment of prognosis. The study highlights the acceptance of these hematological parameters, with practical utility, as prognostic biomarkers in ovarian cancer, based on the intrinsic link with cancer-associated inflammatory mediators. Based on the data from the specialized literature, the conclusion is that in ovarian cancer, the inflammatory process induced by the presence of the tumor, induces changes in the types of circulating leukocytes, with immediate effects on the markers of systemic inflammation.

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“…Similarly, clinical trials targeting SX-682, a small-molecule inhibitor of CXCR1 and CXCR2 in combination with pembrolizumab (anti-PD-1 immunotherapy), are undergoing for metastatic or recurrent stage IIIC or IV non-small cell lung cancer [NCT05570825], metastatic melanoma [NCT03161431], and metastatic colorectal cancer (mCRC) [NCT06149481]. Another mechanism that exploits the tumor-killing ability of neutrophils is using TGF-β-blocking antibodies either as monotherapy or as combination therapy with [ 191 ] fresolimumab, which has been shown to be used in patients with melanoma [ 192 ], renal cell carcinoma [ 193 ], and metastatic breast cancer [ 194 ]. Moreover, fresolimumab and stereotactic ablative radiotherapy is currently being used in early-stage non-small cell lung cancer in phase I/II trials [NCT02581787].…”

Section: Clinical Relevance and Future Directionsmentioning

confidence: 99%

Neutrophils at the Crossroads: Unraveling the Multifaceted Role in the Tumor Microenvironment

Awasthi,

Sarode

2024

IJMS

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Over the past decade, research has prominently established neutrophils as key contributors to the intricate landscape of tumor immune biology. As polymorphonuclear granulocytes within the innate immune system, neutrophils play a pivotal and abundant role, constituting approximately ∼70% of all peripheral leukocytes in humans and ∼10–20% in mice. This substantial presence positions them as the frontline defense against potential threats. Equipped with a diverse array of mechanisms, including reactive oxygen species (ROS) generation, degranulation, phagocytosis, and the formation of neutrophil extracellular traps (NETs), neutrophils undeniably serve as indispensable components of the innate immune system. While these innate functions enable neutrophils to interact with adaptive immune cells such as T, B, and NK cells, influencing their functions, they also engage in dynamic interactions with rapidly dividing tumor cells. Consequently, neutrophils are emerging as crucial regulators in both pro- and anti-tumor immunity. This comprehensive review delves into recent research to illuminate the multifaceted roles of neutrophils. It explores their diverse functions within the tumor microenvironment, shedding light on their heterogeneity and their impact on tumor recruitment, progression, and modulation. Additionally, the review underscores their potential anti-tumoral capabilities. Finally, it provides valuable insights into clinical therapies targeting neutrophils, presenting a promising approach to leveraging innate immunity for enhanced cancer treatment.

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Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications

Cited by 22 publications

References 135 publications

Prognostic value of pan-immune-inflammation value in colorectal cancer patients: A systematic review and meta-analysis

Prognostic value of pan-immune-inflammation value in colorectal cancer patients: A systematic review and meta-analysis

Systemic inflammation factors as survival prognosis markers in ovarian neoplasm and the relationship with cancer-associated inflammatory mediators—a review

Neutrophils at the Crossroads: Unraveling the Multifaceted Role in the Tumor Microenvironment

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