Roles of Tumor-Associated Macrophages in Tumor Environment and Strategies for Targeting Therapy
Meng-Qi Liu,
Jia-Wei Zhang,
Jian-Wei Zhu
Abstract:Tumor-associated macrophages (TAMs) constitute a significant component of the tumor microenvironment. This work reviewed the latest progress in comprehending the function of TAMs and their strategies for cancer therapy. TAMs are highly heterogeneous and plastic and exhibit different functional phenotypes in response to different signal stimuli. The emergence of single-cell technologies allows us to revisit their diversity in cancer. When their pro-inflammatory function is activated, antitumor TAMs support and … Show more
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