Roles of TOR signaling in nutrient deprivation and abiotic stress

Haq, Syed Inzimam Ul; Shang, Jin; Xie, Huichun; Qiu, Quan‐Sheng

doi:10.1016/j.jplph.2022.153716

Cited by 15 publications

(6 citation statements)

References 118 publications

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“…mTOR, as a pivotal regulator of translation initiation and ribosome biogenesis, ful lls an evolutionarily conserved role in regulating cell growth. By activating ribosomal S6K1, mTOR facilitates protein synthesis, thereby engaging in vital biological processes, such as cell growth and metabolic regulation [57]. In this study, the signi cant upregulation of the above genes by B. pumilus indicates its ability to promote host protein synthesis and accumulation via mTOR signaling pathway regulation.…”

Section: Discussionmentioning

confidence: 60%

WITHDRAWN: Effects of dietary Bacillus pumilus on the growth performance, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile Coho salmon (Oncorhynchus kisutch)

Guo,

Meng,

et al. 2024

Preprint

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This study explored and evaluated the addition of the probiotic Bacillus pumilus Rf8 to Coho salmon (Oncorhynchus kisutch) feed. A total of 360 juvenile Coho salmon with an initial body weight of 130.45 ± 1.11 g were randomly divided into four treatment groups, with three replicates per group and 30 fish per replicate. Different concentrations of B. pumilus were added to the feed of the four treatment groups: 0 (control group), 2 × 106, 4 × 108, and 8 × 1010 cfu/g. The experiment lasted 70 days. Growth performance parameters, nutritional metabolism, immune-related serum biochemical indicators, enzyme activity, gene expression, and muscle composition were evaluated. Furthermore, intestinal histology and intestinal flora were assessed. The findings indicated that relative to the control group, B. pumilus Rf8 notably enhanced the growth performance, protein and fat metabolism, and immune status of the fish, effectively bolstering the structure and function of the intestinal microbiota. The “4 × 108 cfu/g concentration” group demonstrated a substantial advantage in juvenile fish. The B. pumilus strains identified in this study exhibit promising potential as probiotic feed supplements in Coho salmon aquaculture.

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Section: Discussionmentioning

confidence: 60%

WITHDRAWN: Effects of dietary Bacillus pumilus on the growth performance, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile Coho salmon (Oncorhynchus kisutch)

Guo,

Meng,

et al. 2024

Preprint

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“…Large increases in soluble sugar levels would also be expected to have a profound effect on TOR signalling acting to promote TOR activation of ribosome biogenesis, cell division and growth (Li and Sheen, 2016; Haq et al, 2022; Jindal et al, 2022). Indeed, a highly significant (p<2.2E-16) positive correlation (r=0.44) was observed between the previously published responses of Arabidopsis TOR-regulated transcripts to a two-hour treatment with 15 mM glucose in A. thaliana seedlings (Xiong et al, 2013) and the responses of their S. viridis orthologs to prolonged heat stress in this study (Supplementary Figure 12A).…”

Section: Discussionmentioning

confidence: 99%

Systems analysis of long-term heat stress responses in the C₄grassSetaria viridis

Zhang,

Sharwood,

Carroll

et al. 2023

Preprint

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A substantial number of C4plants are utilized as food and fodder crops and often display improved resource use efficiency compared to C3counterparts. However, their response to future extreme climates such as heatwaves is less understood.Setaria viridis, an emerging C4model grass closely related to important C4 crops, was grown under high temperature for two weeks (42°C as compared to 28°C). High temperature resulted in stunted growth, but surprisingly had little impact on leaf area based photosynthetic rates. Rates of dark respiration significantly increased and there were major alterations in carbon and nitrogen metabolism in the heat-stressed plants, including reduced starch levels, accumulation of soluble sugars and an increase in leaf nitrogen content. Measurements of major phytohormones revealed a dramatic increase in abscisic acid in the heat-stressed plants. Leaf transcriptomics, proteomics and metabolomics analyses were carried out and mapped onto metabolic pathways of photosynthesis, respiration, carbon/nitrogen metabolism and hormone synthesis and signaling. Overall, upregulation of a number of stress-signaling pathways was observed, consistent with multiple potent signals leading to reduced plant growth. A systems model of plant response is presented based on oxidative stress, hormone and sugar signaling pathways.

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“…Other enriched functions of BvWD40s also showed correlation with salt stress, such as peroxisome biogenesis, TOR signal transduction, MAPK complex, Katanin complex, RNA binding, autophagy, and ubiquitination. Previous studies have shown that OsPEX11, a peroxisome biogenesis factor in rice, contributes to salt stress tolerance in rice (Cui et al, 2016), TOR signaling is necessary during plant stress (Haq et al, 2022), and MAPK can mediate salt stress signal transduction in plants (Wu et al, 2023). AtKATANIN1, which encodes a microtubule cutting protein, regulates microtubule depolymerization in response to salt stress in Arabidopsis (Yang et al, 2019).…”

Section: The Bvwd40 Genes Are Involved In Many Biological Processesmentioning

confidence: 99%

Genome-wide analysis of WD40 protein family and functional characterization of BvWD40-82 in sugar beet

Zhang

et al. 2023

Front. Plant Sci.

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Sugar beet is one of the most important sugar crops in the world. It contributes greatly to the global sugar production, but salt stress negatively affects the crop yield. WD40 proteins play important roles in plant growth and response to abiotic stresses through their involvement in a variety of biological processes, such as signal transduction, histone modification, ubiquitination, and RNA processing. The WD40 protein family has been well-studied in Arabidopsis thaliana, rice and other plants, but the systematic analysis of the sugar beet WD40 proteins has not been reported. In this study, a total of 177 BvWD40 proteins were identified from the sugar beet genome, and their evolutionary characteristics, protein structure, gene structure, protein interaction network and gene ontology were systematically analyzed to understand their evolution and function. Meanwhile, the expression patterns of BvWD40s under salt stress were characterized, and a BvWD40-82 gene was hypothesized as a salt-tolerant candidate gene. Its function was further characterized using molecular and genetic methods. The result showed that BvWD40-82 enhanced salt stress tolerance in transgenic Arabidopsis seedlings by increasing the contents of osmolytes and antioxidant enzyme activities, maintaining intracellular ion homeostasis and increasing the expression of genes related to SOS and ABA pathways. The result has laid a foundation for further mechanistic study of the BvWD40 genes in sugar beet tolerance to salt stress, and it may inform biotechnological applications in improving crop stress resilience.

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Roles of TOR signaling in nutrient deprivation and abiotic stress

Cited by 15 publications

References 118 publications

WITHDRAWN: Effects of dietary Bacillus pumilus on the growth performance, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile Coho salmon (Oncorhynchus kisutch)

WITHDRAWN: Effects of dietary Bacillus pumilus on the growth performance, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile Coho salmon (Oncorhynchus kisutch)

Systems analysis of long-term heat stress responses in the C₄grassSetaria viridis

Genome-wide analysis of WD40 protein family and functional characterization of BvWD40-82 in sugar beet

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Roles of TOR signaling in nutrient deprivation and abiotic stress

Cited by 15 publications

References 118 publications

WITHDRAWN: Effects of dietary Bacillus pumilus on the growth performance, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile Coho salmon (Oncorhynchus kisutch)

WITHDRAWN: Effects of dietary Bacillus pumilus on the growth performance, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile Coho salmon (Oncorhynchus kisutch)

Systems analysis of long-term heat stress responses in the C4grassSetaria viridis

Genome-wide analysis of WD40 protein family and functional characterization of BvWD40-82 in sugar beet

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Product

Resources

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Systems analysis of long-term heat stress responses in the C₄grassSetaria viridis