Roles of the spleen in acute plasmodial and babesial infections in rats

Todorovic, R. A.; Ferris, D. H.; Ristić, M

doi:10.1016/0014-4894(67)90096-3

Cited by 31 publications

(7 citation statements)

References 29 publications

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“…Intra‐erythrocytic haemoparasite removal (in a process called ‘pitting’) is an important function of the macrophage population of the spleen during haemoprotozoal infections . An older study evaluated the rate of erythrocyte loss in splenectomized B. rodhaini and B. microti ‐infected rats . The authors demonstrated that splenectomy does not abolish but only delays the loss of erythrocytes suggesting that monocyte‐macrophages of liver and bone marrow origin take over this phagocytic function .…”

Section: Discussionmentioning

confidence: 99%

“…An older study evaluated the rate of erythrocyte loss in splenectomized B. rodhaini and B. microti ‐infected rats . The authors demonstrated that splenectomy does not abolish but only delays the loss of erythrocytes suggesting that monocyte‐macrophages of liver and bone marrow origin take over this phagocytic function . The spleen does however play a very important role in the clearance of haemoprotozoal organisms as evidenced by the death of splenectomized rats infected with Plasmodium berghei .…”

Section: Discussionmentioning

confidence: 99%

“…40 The authors demonstrated that splenectomy does not abolish but only delays the loss of erythrocytes suggesting that monocyte-macrophages of liver and bone marrow origin take over this phagocytic function. 40 The spleen does however play a very important role in the clearance of haemoprotozoal organisms as evidenced by the death of splenectomized rats infected with Plasmodium berghei. 40 Another study, similar in methodology, showed the importance of macrophages during the control of both the acute and resolving infections of Babesia microti in mice.…”

Section: Discussionmentioning

confidence: 99%

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The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi

Henning

Clift

Leisewitz

2020

Parasite Immunology

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To provide useful information based on the macropathology, histopathology and immunohistochemical investigation in the spleens of dogs with Babesia rossi infection. Control spleens were collected from four healthy dogs euthanized for welfare reasons. Nine dogs that died naturally because of a mono‐infection with Babesia rossi were selected for the diseased group. One haematoxylin‐and‐eosin–stained section of splenic tissue from each of the infected and control dogs was examined under the light microscope. Immunohistochemical markers were applied to characterize different immunocyte populations. The application of analytic software enabled semi‐quantitative comparison of leucocyte subpopulations. Routine splenic histopathology revealed diffuse intermingling of white and red pulp from infected dogs with a clear loss of distinction between these zones. Immunohistochemistry revealed an increase in the proportion of tissue resident and bone marrow origin macrophages in the infected spleens. Apart from a few remnant lymphocytes within the peri‐arteriolar lymphatic sheaths and follicles, the majority of the immunocytes redistributed to the red pulp, supporting the observation of white and red pulp intermingling. The majority of our findings are in agreement with histomorphological descriptions of the spleen in a variety of noncanid mammalian hosts with lethal malaria or babesiosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi

Henning

Clift

Leisewitz

2020

Parasite Immunology

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“…The spleen is critical to acquisition and maintenance of immunity to blood-borne protozoan infections ( 18), and, in malaria, splenomegaly is a feature of recovery (16). Thus, it is to be expected that some acquired spleen function might be transferable from an immune host which Each point is the mean parasitemia from 8 rats.…”

Section: Discussionmentioning

confidence: 99%

Adoptive Transfer of Immunity to Plasmodium berghei

Roberts

Tracey-Patte

1969

The Journal of Protozoology

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SYNOPSIS. Immunity to P. berghei in rats was transferred adoptively with spleen cells but not with bone marrow cells, thymus cells, peripheral lymph node cells or thoracic duct lymphocytes from immune donors. The parasite multiplies at the same rate in control and protected rats but when about 10% of host red cells are infected the number of infected cells in protected rats decreases rapidly whereas control rats attain high parasitemias and die. Serum from immune donors delays the onset of parasitemia but does not affect its ultimate course or the fate of the recipient.

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“…All treatments resulted in an increased amount of regenerated splenic tissue [8]. The functional capacity of splenic transplants after stimulating the white pulp was tested by measuring the protection afforded against rodent malaria, since it is known that the spleen plays an important role in malaria infection [19,23]. A surprising result was that stimulated transplants did not provide better protection than saline-injected controls [11].…”

Section: Introductionmentioning

confidence: 99%

Malaria infection in rats with stimulated splenic red pulp: The blood flow and protective effect in normal and transplanted splenic tissue

Westermann

Pabst

1988

Res. Exp. Med.

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After splenic autotransplantation both weight and blood flow of the regenerated splenic tissue are decreased. In addition, the protective function of the transplant is less compared to that of the normal spleen. In the present study, the red pulp of normal and transplanted splenic tissue was stimulated by injections of phenylhydrazine to increase the weight, the blood flow, and the protective function. After stimulation, the weight of the normal spleen increased to 900 +/- 70 mg (control 530 +/- 20 mg) and the transplanted tissue to 240 +/- 70 mg (control 70 +/- 20 mg). This enlargement was caused by an increase in the splenic red pulp. However, the relative blood flow decreased in both the normal spleen and the transplant to 50% of the normal value. To evaluate the protective function of the stimulated splenic tissue, normal, splenectomized and transplanted rats were infected with Plasmodium berghei. Despite the dramatic increase in the red pulp, neither the normal nor the transplanted animals showed a survival rate superior to that of the splenectomized animals. The mass of splenic tissue obviously does not correlate with the protective effect of the spleen in parasitic infections.

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Roles of the spleen in acute plasmodial and babesial infections in rats

Cited by 31 publications

References 29 publications

The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi

The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi

Adoptive Transfer of Immunity to Plasmodium berghei

Malaria infection in rats with stimulated splenic red pulp: The blood flow and protective effect in normal and transplanted splenic tissue

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