Roles of the Notch signaling pathway and microglia in autism

Zhang, Yinghua; Wang, Ting; Li, Yanfang; Deng, Yongbo; Shen, Fangzhong

doi:10.1016/j.bbr.2022.114131

Cited by 13 publications

(7 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a neurodevelopmental disorder, autism is associated with an abnormal increase in the number of microglia in several brain regions ( 70 ). Some studies have reported that the occurrence of autism is related to the pruning and stability of synapses ( 71 , 72 ).…”

Section: Resultsmentioning

confidence: 99%

Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis

Li,

Lu,

Zhang

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

AimsAutism is a multifaceted developmental disorder of the nervous system, that necessitates novel therapeutic approaches beyond traditional medications and psychosomatic therapy, such as appropriate sensory integration training. This systematic mapping review aims to synthesize existing knowledge on enriching environmental interventions as an alternative avenue for improving autism, guiding future research and practice.MethodA comprehensive search using the terms ASD and Enriched Environment was conducted across PubMed, EMBASE, ISI, Cochrane, and OVID databases. Most of the literature included in this review was derived from animal model experiments, with a particular focus on assessing the effect of EE on autism-like behavior, along with related pathways and molecular mechanisms. Following extensive group discussion and screening, a total of 19 studies were included for analysis.ResultsEnriched environmental interventions exhibited the potential to induce both behavioral and biochemical changes, ameliorating autism-like behaviors in animal models. These improvements were attributed to the targeting of BDNF-related pathways, enhanced neurogenesis, and the regulation of glial inflammation.ConclusionThis paper underscores the positive impact of enriched environmental interventions on autism through a review of existing literature. The findings contribute to a deeper understanding of the underlying brain mechanisms associated with this intervention.

show abstract

Section: Resultsmentioning

confidence: 99%

Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis

Li,

Lu,

Zhang

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…The Notch signaling pathway is a well-established developmental pathway in brain morphogenesis [ 14 ]. It exerts momentous roles in regulating neural stem cell proliferation, survival, and differentiation during central nervous system development [ 15 ]. In addition, dysfunction of the Notch signaling pathway is related to multiple nervous system diseases, including ASD [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive exosomal microRNA profile and construction of competing endogenous RNA network in autism spectrum disorder: A pilot study

Zhao,

Zhong,

Shen

et al. 2024

Biomol Biomed

View full text Add to dashboard Cite

Exosomes have been demonstrated to exert momentous roles in autism spectrum disorder (ASD). However, few studies have reported a correlation between exosomal microRNAs (miRNAs) and ASD. To date, our understanding of crucial competing endogenous RNA (ceRNA) networks in ASD remains limited. Herein, the exosomal miRNA profile in the peripheral blood of children with ASD and healthy controls was investigated and the level of immune cell infiltration in ASD was evaluated to determine the distribution of immune cell subtypes. Exosomes were isolated from the peripheral blood of 10 children with ASD and 10 healthy controls, and further identified using transmission electron microscopy and western blot analysis. RNA sequencing was conducted to investigate exosomal miRNA profiles in patients with ASD. The mRNA and circular RNA (circRNA) expression profiles were acquired from the GEO database. Differentially expressed mRNAs (DEmRNAs), miRNAs (DEmiRNAs), and circRNAs (DEcircRNAs) were identified and ceRNA regulatory networks were constructed. Furthermore, the immune cell infiltration levels in patients with ASD were evaluated. Exosomes were spherical, approximately 100 nm in size, and were confirmed via western blot analysis using exosome-associated markers CD9, CD63, and CD81. Thirty-five DEmRNAs, 63 DEmiRNAs, and 494 DEcircRNAs were identified in patients with ASD. CeRNA regulatory networks, including 6 DEmRNAs, 14 DEmiRNAs, and 86 DEcircRNAs, were established. Correlation analysis indicated that leucine-rich glioma inactivated protein 1 (LGI1) expression was significantly positively correlated with the content of CD8+ T cells. Our findings may be conducive to offering novel insights into this disease and providing further evidence of transcriptomic abnormalities in ASD.

show abstract

“…The activation of NOTCH1 signaling in the dorsal horn of spinal cord increases the excitability of neurons, while its inhibition inhibits the excitability of neurons (29). In addition, the activation of NOTCH1 signaling can promote the differentiation of neural stem cells into astrocytes and microglia, which is related to synaptic remodeling and nerve regeneration (30). In an animal model of peripheral nerve injury, the activation of NOTCH1 signaling also activated glial cells, suggesting its important role in the plasticity of the adult nervous system after injury (31,32).…”

Section: Discussionmentioning

confidence: 99%

Involvement of NOTCH1-mediated Microglia Activation in Neuromodulation of Chronic Prostatitis-related Pain

ZHANG,

GU,

LUO

et al. 2024

In Vivo

View full text Add to dashboard Cite

Background/Aim: This study aimed to investigate the role of NOTCH receptor 1 (NOTCH1)-mediated activation of microglia in the L5-S2 spinal dorsal horn in chronic prostatitis pain. Materials and Methods: Rats were divided into chronic prostatitis (CP) group and control group. Complete Freund's adjuvant was injected into the prostate, and prostate pathology and pain-related behavior were monitored to assess the successful establishment of the CPrelated pain model. The dorsal horn of the L5-S2 spinal cord was collected for the detection of ionized calcium-binding adapter molecule 1 (IBA-1) and NOTCH1 expression by quantitative real time polymerase chain reaction and the detection of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) by enzyme-linked immunosorbent assay. Electrical excitability was assessed with whole-cell patch clamp. In addition, NOTCH1 receptor inhibitor or inhibitor of microglial cell activation was injected into the subarachnoid space, and the pro-inflammatory cytokines in the spinal cord were detected. Results: In the CP group, the expression of NOTCH1, IBA-1, TNF-α and IL-1β began to increase at 4 days, peaked at 12 days, and began to decline at 24 days, and it was significantly higher than in the control group (p<0.01). Inhibition of microglia or NOTCH1 receptor markedly reduced the content of TNF-α and IL-1β in the spinal cord (p<0.05). At 4, 12 and 24 days, the amplitude and frequency of neuronal action potential increased and the threshold decreased markedly as compared to the control

show abstract

Roles of the Notch signaling pathway and microglia in autism

Cited by 13 publications

References 72 publications

Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis

Molecular insights into enriched environments and behavioral improvements in autism: a systematic review and meta-analysis

Comprehensive exosomal microRNA profile and construction of competing endogenous RNA network in autism spectrum disorder: A pilot study

Involvement of NOTCH1-mediated Microglia Activation in Neuromodulation of Chronic Prostatitis-related Pain

Contact Info

Product

Resources

About