Roles of ten‑eleven translocation family proteins and their O‑linked &amp;beta;‑N‑acetylglucosaminylated forms in cancer development (Review)

Li, Hongjiao; Wang, Yi; Li, Bingxin; Yang, Yang; Guan, Feng; Pang, Xingchen; Li, Xiang

doi:10.3892/ol.2020.12262

Cited by 42 publications

(40 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiR-15a-5p inhibits CADM1 which stimulates Akt phosphorylation. Akt, also known as protein kinase B, is an important protein regulating cell proliferation which is over-activated in GB tissues and cells ( Figure 5 ) [ 60 ].…”

Section: Microrna In Glioblastomamentioning

confidence: 99%

See 1 more Smart Citation

Glioblastoma and MiRNAs

Ahmed

Castresana

Shahi

2021

Cancers

View full text Add to dashboard Cite

Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. GB is chemo and radio resistant. Thus, there is a critical need for new insights into GB treatment to increase the chance of therapeutic success. This is why microRNA (miRNA) is being potentially considered in the diagnosis and treatment of glioblastoma. The objective of our review is to provide a holistic picture of GB up-regulated and down-regulated miRNA, in relationship with the expression of other genes, cell signaling pathways, and their role in GB diagnosis and treatment. MiRNA treatment is being considered to be used against GB together with radiotherapy and chemotherapy. Moreover, the use of miRNA as a diagnostic tool has also begun. Knowing that miRNAs are isolated in almost all human body fluids and that there are more than 3000 miRNAs in the human genome, plus the fact that each miRNA controls hundreds of different mRNAs, there is still much study needed to explore how miRNAs relate to GB for its proliferation, progression, and inhibition.

show abstract

Section: Microrna In Glioblastomamentioning

confidence: 99%

“…The overexpression of miR-640 promotes growth in human GB cell lines by targeting and suppressing slit guidance ligand 1 (SLIT1). Therefore, the miR-640/SLIT1 axis may be a novel potential therapeutic target for the treatment and diagnosis of GB ( Figure 5 ) [ 62 ].…”

Section: Microrna In Glioblastomamentioning

confidence: 99%

Glioblastoma and MiRNAs

Ahmed

Castresana

Shahi

2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Another oncosuppressive microRNA is miR-126. Studies have shown that miR-126 can inhibit the proliferation of NSCLC through the suppression of EGFL7 and PTEN/PI3K/AKT signaling pathways [ 38 , 39 ]. In addition, decreased expression of miR-126 was associated with adhesion, migration, and invasion of NSCLC cells due to an increase in the Crk protein [ 40 ].…”

Section: Asbestos As a Carcinogenic Factor Of The Environmentmentioning

confidence: 99%

Role of microRNAs in Lung Carcinogenesis Induced by Asbestos

Bersimbaev

Bulgakova

Aripova

et al. 2021

JPM

View full text Add to dashboard Cite

MicroRNAs are a class of small noncoding endogenous RNAs 19–25 nucleotides long, which play an important role in the post-transcriptional regulation of gene expression by targeting mRNA targets with subsequent repression of translation. MicroRNAs are involved in the pathogenesis of numerous diseases, including cancer. Lung cancer is the leading cause of cancer death in the world. Lung cancer is usually associated with tobacco smoking. However, about 25% of lung cancer cases occur in people who have never smoked. According to the International Agency for Research on Cancer, asbestos has been classified as one of the cancerogenic factors for lung cancer. The mechanism of malignant transformation under the influence of asbestos is associated with the genotoxic effect of reactive oxygen species, which initiate the processes of DNA damage in the cell. However, epigenetic mechanisms such as changes in the microRNA expression profile may also be implicated in the pathogenesis of asbestos-induced lung cancer. Numerous studies have shown that microRNAs can serve as a biomarker of the effects of various adverse environmental factors on the human body. This review examines the role of microRNAs, the expression profile of which changes upon exposure to asbestos, in key processes of carcinogenesis, such as proliferation, cell survival, metastasis, neo-angiogenesis, and immune response avoidance.

show abstract

Section: Future Researchmentioning

confidence: 99%

“…Ten-eleven translocation (TET) are important drivers of cancer initiation and progression via the regulation of epigenetic processes [ 202 ]. O-GlcNAcylation potentiates TET effects, including via DNA demethylation and histone methylation [ 202 ]. The interactions of O-GlcNAcylated TET with the AhR/AHRR and mitochondrial function in cells of the tumour microenvironment will be important to determine, especially as this has been proposed to underpin AhR-driven active DNA demethylation and thereby epigenetic memory [ 203 ].…”

Section: Future Researchmentioning

confidence: 99%

Tumour Microenvironment: Roles of the Aryl Hydrocarbon Receptor, O-GlcNAcylation, Acetyl-CoA and Melatonergic Pathway in Regulating Dynamic Metabolic Interactions across Cell Types—Tumour Microenvironment and Metabolism

Anderson¹

2020

IJMS

View full text Add to dashboard Cite

This article reviews the dynamic interactions of the tumour microenvironment, highlighting the roles of acetyl-CoA and melatonergic pathway regulation in determining the interactions between oxidative phosphorylation (OXPHOS) and glycolysis across the array of cells forming the tumour microenvironment. Many of the factors associated with tumour progression and immune resistance, such as yin yang (YY)1 and glycogen synthase kinase (GSK)3β, regulate acetyl-CoA and the melatonergic pathway, thereby having significant impacts on the dynamic interactions of the different types of cells present in the tumour microenvironment. The association of the aryl hydrocarbon receptor (AhR) with immune suppression in the tumour microenvironment may be mediated by the AhR-induced cytochrome P450 (CYP)1b1-driven ‘backward’ conversion of melatonin to its immediate precursor N-acetylserotonin (NAS). NAS within tumours and released from tumour microenvironment cells activates the brain-derived neurotrophic factor (BDNF) receptor, TrkB, thereby increasing the survival and proliferation of cancer stem-like cells. Acetyl-CoA is a crucial co-substrate for initiation of the melatonergic pathway, as well as co-ordinating the interactions of OXPHOS and glycolysis in all cells of the tumour microenvironment. This provides a model of the tumour microenvironment that emphasises the roles of acetyl-CoA and the melatonergic pathway in shaping the dynamic intercellular metabolic interactions of the various cells within the tumour microenvironment. The potentiation of YY1 and GSK3β by O-GlcNAcylation will drive changes in metabolism in tumours and tumour microenvironment cells in association with their regulation of the melatonergic pathway. The emphasis on metabolic interactions across cell types in the tumour microenvironment provides novel future research and treatment directions.

show abstract

Roles of ten‑eleven translocation family proteins and their O‑linked β‑N‑acetylglucosaminylated forms in cancer development (Review)

Cited by 42 publications

References 79 publications

Glioblastoma and MiRNAs

Glioblastoma and MiRNAs

Role of microRNAs in Lung Carcinogenesis Induced by Asbestos

Tumour Microenvironment: Roles of the Aryl Hydrocarbon Receptor, O-GlcNAcylation, Acetyl-CoA and Melatonergic Pathway in Regulating Dynamic Metabolic Interactions across Cell Types—Tumour Microenvironment and Metabolism

Contact Info

Product

Resources

About