Roles of SNORD115 and SNORD116 ncRNA clusters in neuronal differentiation
Aleksandra Helwak,
Tomasz Turowski,
Christos Spanos
et al.
Abstract:Prader-Willi syndrome shows features linked to brain development and hypothalamus-related endocrine abnormalities. The smallest clinical deletions fall within the large (~650Kb) SNHG14 gene, removing 29 consecutive introns that each generate SNORD116. SNHG14 also includes 48 tandem introns encoding SNORD115 and generates multiple, extended snoRNA-related species. SNORD115 and SNORD116 resemble box C/D small nucleolar RNAs (snoRNAs) but lack known targets. Both snoRNAs strongly accumulated during neuronal diffe… Show more
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