Roles of small RNAs in the establishment of tolerant interaction between plants and viruses

Križnik, Maja; Baebler, Špela; Gruden, Kristina

doi:10.1016/j.coviro.2020.04.006

Cited by 14 publications

(10 citation statements)

References 73 publications

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“…Growing evidence shows that the host‐encoded miRNAs could modulate virus replication and pathogenesis (Khan et al, 2020 ; Tribolet et al, 2020 ; Wong et al, 2020 ; Zhang et al, 2020 ; Zheng et al, 2020 ). miRNAs through binding with viral RNA interact with different species or strain of viruses (Križnik et al, 2020 ; Trobaugh & Klimstra, 2017 ). miRNAs by binding to the 3′‐UTR (El‐Nabi et al, 2020 ; Liu et al, 2017 ) or 5′‐UTR of viral RNA play an important role in COVID‐19‐host interplay and viral replication (Demirci & Adan, 2020 ; Nersisyan et al, 2020 ).…”

Section: The Potential Function Of Mirnas Following Covid‐19 Infectionmentioning

confidence: 99%

miRNAs; a novel strategy for the treatment of COVID‐19

Hao

Ebrahimi

Keivan

et al. 2021

Cell Biology International

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Coronavirus disease 2019 (COVID‐19) is the seventh member of the bat severe acute respiratory syndrome family. COVID‐19 can fuse their envelopes with the host cell membranes and deliver their genetic material. COVID‐19 attacks the respiratory system and stimulates the host inflammatory responses, enhances the recruitment of immune cells, and promotes angiotensin‐converting enzyme 2 activities. Patients with confirmed COVID‐19 may have experienced fever, dry cough, headache, dyspnea, acute kidney injury, acute respiratory distress syndrome, and acute heart injury. Several strategies such as oxygen therapy, ventilation, antibiotic or antiviral therapy, and renal replacement therapy are commonly used to decrease COVID‐19‐associated mortality. However, these approaches may not be good treatment options. Therefore, the search for an alternative‐novel therapy is urgently important to prevent the disease progression. Recently, microRNAs (miRNAs) have emerged as a promising strategy for COVID‐19. The design of oligonucleotide against the genetic material of COVID‐19 might suppress virus RNA translation. Several previous studies have shown that host miRNAs play an antiviral role and improve the treatment of patients with COVID‐19. miRNAs by binding to the 3′‐untranslated region (UTR) or 5′‐UTR of viral RNA play an important role in COVID‐19‐host interplay and viral replication. miRNAs interact with multiple pathways and reduce inflammatory biomarkers, thrombi formation, and tissue damage to accelerate the patient outcome. The information in this review provides a summary of the current clinical application of miRNAs for the treatments of patients with COVID‐19.

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Section: The Potential Function Of Mirnas Following Covid‐19 Infectionmentioning

confidence: 99%

miRNAs; a novel strategy for the treatment of COVID‐19

Hao

Ebrahimi

Keivan

et al. 2021

Cell Biology International

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“…We reported the top hits of these searches in Supplemental Files S1 and S4 to provide a link between the potato genome online resources and NCBI resources to facilitate comparative analyses between the potato genes/proteins with other organisms. Analyses of small RNAs including 21-and 24-nt small RNAs and miRNAs from the same time points indicate similarities to tolerant infections in other potato cultivars, expanding upon and further solidifying the results of the few other studies that have examined small RNAs in PVY-infected potato [73,74,102]. Tolerant plants may serve as viral reservoirs that may produce recombinant viruses and/or outbreaks and, therefore, tolerance to PVY infection is not a useful trait for potato breeders.…”

Section: Discussionmentioning

confidence: 76%

“…Importantly, Russet Burbank plants in this study were largely asymptomatic and did not display any chlorosis or strong mosaic symptoms. Since PVY reached high levels of systemic infection without obvious phenotypic effects on the plants, infections in this study could be categorized as tolerant [ 13 , 73 , 74 , 75 ]. This description is also congruent with the gene expression changes observed in this study (i.e., lower expression of defense genes and higher expression of genes involved in photosynthesis and chloroplast function).…”

Section: Resultsmentioning

confidence: 99%

Transcriptome and Small RNA Profiling of Potato Virus Y Infected Potato Cultivars, Including Systemically Infected Russet Burbank

Ross

Zidack

McDonald

et al. 2022

Viruses

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Potatoes are the world’s most produced non-grain crops and an important food source for billions of people. Potatoes are susceptible to numerous pathogens that reduce yield, including Potato virus Y (PVY). Genetic resistance to PVY is a sustainable way to limit yield and quality losses due to PVY infection. Potato cultivars vary in their susceptibility to PVY and include susceptible varieties such as Russet Burbank, and resistant varieties such as Payette Russet. Although the loci and genes associated with PVY-resistance have been identified, the genes and mechanisms involved in limiting PVY during the development of systemic infections have yet to be fully elucidated. To increase our understanding of PVY infection, potato antiviral responses, and resistance, we utilized RNA sequencing to characterize the transcriptomes of two potato cultivars. Since transcriptional responses associated with the extreme resistance response occur soon after PVY contact, we analyzed the transcriptome and small RNA profile of both the PVY-resistant Payette Russet cultivar and PVY-susceptible Russet Burbank cultivar 24 h post-inoculation. While hundreds of genes, including terpene synthase and protein kinase encoding genes, exhibited increased expression, the majority, including numerous genes involved in plant pathogen interactions, were downregulated. To gain greater understanding of the transcriptional changes that occur during the development of systemic PVY-infection, we analyzed Russet Burbank leaf samples one week and four weeks post-inoculation and identified similarities and differences, including higher expression of genes involved in chloroplast function, photosynthesis, and secondary metabolite production, and lower expression of defense response genes at those time points. Small RNA sequencing identified different populations of 21- and 24-nucleotide RNAs and revealed that the miRNA profiles in PVY-infected Russet Burbank plants were similar to those observed in other PVY-tolerant cultivars and that during systemic infection ~32% of the NLR-type disease resistance genes were targeted by 21-nt small RNAs. Analysis of alternative splicing in PVY-infected potato plants identified splice variants of several hundred genes, including isoforms that were more dominant in PVY-infected plants. The description of the PVYN-Wi-associated transcriptome and small RNA profiles of two potato cultivars described herein adds to the body of knowledge regarding differential outcomes of infection for specific PVY strain and host cultivar pairs, which will help further understanding of the mechanisms governing genetic resistance and/or virus-limiting responses in potato plants.

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“…Thus, miR156 overexpression increased drought stress tolerance. In turn, Križnik et al (2020) [26] suggested that miR156 in Nicotianas can participate in plant resistance to viral infection. The targets of miR159 are MYB genes [82], which are transcription factor genes that control different processes, including responses to biotic and abiotic stress, as well as plant tolerance to metal stress [83,84].…”

Section: Effect Of Fe 3 O 4 Nanoparticles On Barley Mirna Expressionmentioning

confidence: 99%

“…Furthermore, miR159c is known to be involved in the response to fungal infection in wheat [25]. However, miR156 can be involved in resistance to viral infection [26]. According to Yao et al (2021) [27], miR156 and miR159 families' targets are at least three genes that are related to the resistance of Tibetan hulless barley against fungal diseases, such as barley leaf stripe [27].…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Evaluation of Fe3O4 Nanoparticles in Different Three Barley (Hordeum vulgare L.) Genotypes to Explore the Stress-Resistant Molecules

et al. 2021

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Sustainable agricultural practices are still essential due to soil degradation and crop losses. Recently, the relationship between plants and nanoparticles (NPs) attracted scientists’ attention, especially for applications in agricultural production as nanonutrition. Therefore, the present research was carried out to investigate the effect of Fe3O4 NPs at low concentrations (0, 1, 10, and 20 mg/L) on three genotypes of barley (Hordeum vulgare L.) seedlings grown in hydroponic conditions. Significant increases in seedling growth, enhanced chlorophyll quality and quantity, and two miRNA expression levels were observed. Additionally, increased genotoxicity was observed in seedlings grown with NPs. Generally, Fe3O4 NPs at low concentrations could be successfully used as nanonutrition for increasing barley photosynthetic efficiency with consequently enhanced yield. These results are important for a better understanding of the potential impact of Fe3O4 NPs at low concentrations in agricultural crops and the potential of these NPs as nanonutrition for barley growth and yield enhancement. Future studies are needed to investigate the effect of these NPs on the expression of resistance-related genes and chlorophyll synthesis-related gene expression in treated barley seedlings.

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Roles of small RNAs in the establishment of tolerant interaction between plants and viruses

Cited by 14 publications

References 73 publications

miRNAs; a novel strategy for the treatment of COVID‐19

miRNAs; a novel strategy for the treatment of COVID‐19

Transcriptome and Small RNA Profiling of Potato Virus Y Infected Potato Cultivars, Including Systemically Infected Russet Burbank

Genotoxic Evaluation of Fe3O4 Nanoparticles in Different Three Barley (Hordeum vulgare L.) Genotypes to Explore the Stress-Resistant Molecules

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