Roles of presynaptic P/Q- and N-type calcium channels in inhibition of synaptic vesicle exocytosis by isoflurane in rat hippocampal neurones

Abstract

increased and wake time after sleep onset was decreased during melatonin treatment (both P¼0.04). Latency and efficiency were not affected. Participants gave positive feedback on the acceptability of trial design and organisation. We report here that the trial design for MIDNIGHT was both feasible and acceptable and that melatonin treatment in healthy night shift workers was well tolerated. During the first two night shifts staff reported sleepiness and had slower reaction times but showed signs of adaptation by shift 3. The study was not powered to show effects of melatonin, but there was some evidence that mid shift sleepiness was decreased and subjects slept longer when they took melatonin. These data will inform a sample size calculation for a definitive trial.