Roles of platelets in tumor invasion and metastasis: A review

Bian, Xiulan; Yin, Shengjie; Yang, Shuo; Jiang, Xinju; Wang, Jiaqi; Zhang, Minghui; Zhang, Lei

doi:10.1016/j.heliyon.2022.e12072

Cited by 18 publications

(16 citation statements)

References 96 publications

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“…With the progression, especially to the advanced stage of the tumor, not only the TGFβ released from the tumor tissue into the blood will be greatly increased but also the tumor cells themselves will enter the blood and become circulating tumor cells (CTCs), resulting in tumor metastasis ( 23 ). TGFβ derived from tumor tissue and CTCs activate platelets in the blood, which (platelets) also express TGFβ and adhere to the surface of CTCs and wrap the CTCs to protect them from attack by immune cells ( 24 , 25 ). In addition, activated platelets will secrete a large amount of TGFβ which further inhibits immune cells in the blood and even inhibits the function of the entire immune system, thus inhibiting the antitumor immune response of the body ( 25 )—that is to say, the blood F ib (denoted as F ibb ) contains the information of activity of solid tumors.…”

Section: Resultsmentioning

confidence: 99%

“…TGFβ derived from tumor tissue and CTCs activate platelets in the blood, which (platelets) also express TGFβ and adhere to the surface of CTCs and wrap the CTCs to protect them from attack by immune cells ( 24 , 25 ). In addition, activated platelets will secrete a large amount of TGFβ which further inhibits immune cells in the blood and even inhibits the function of the entire immune system, thus inhibiting the antitumor immune response of the body ( 25 )—that is to say, the blood F ib (denoted as F ibb ) contains the information of activity of solid tumors. In this way, we can use the patient’s F ibb multiplied by the patient’s total blood volume (written as V b ) to obtain the tumor ecological momentum of blood (written as M teb ).…”

Section: Resultsmentioning

confidence: 99%

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From immune equilibrium to tumor ecodynamics

Chen

2024

Front. Oncol.

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ObjectivesThere is no theory to quantitatively describe the complex tumor ecosystem. At the same time, cancer immunotherapy is considered a revolution in oncology, but the methods used to describe tumors and the criteria used to evaluate efficacy are not keeping pace. The purpose of this study is to establish a new theory for quantitatively describing the tumor ecosystem, innovating the methods of tumor characterization, and establishing new efficacy evaluation criteria for cancer immunotherapy.MethodsBased on the mathematization of immune equilibrium theory and the establishment of immunodynamics in a previous study, the method of reverse immunodynamics was used, namely, the immune braking force was regarded as the tumor ecological force and the immune force was regarded as the tumor ecological braking force, and the concept of momentum in physics was applied to the tumor ecosystem to establish a series of tumor ecodynamic equations. These equations were used to solve the fundamental and applied problems of the complex tumor ecosystem.ResultsA series of tumor ecodynamic equations were established. The tumor ecological momentum equations and their component factors could be used to distinguish disease progression, pseudoprogression, and hyperprogression in cancer immunotherapy. On this basis, the adjusted tumor momentum equations were established to achieve the equivalence of tumor activity (including immunosuppressive activity and metabolic activity) and tumor volume, which could be used to calculate individual disease remission rate and establish new efficacy evaluation criteria (ieRECIST) for immunotherapy of solid tumor based on tumor ecodynamics. At the same time, the concept of moving cube-to-force square ratio and its expression were proposed to calculate the area under the curve of tumor ecological braking force of blood required to achieve an individual disease remission rate when the adjusted tumor ecological momentum was known.ConclusionsA new theory termed tumor ecodynamics emphasizing both tumor activity and tumor volume is established to solve a series of basic and applied problems in the complex tumor ecosystem. It can be predicted that the future will be the era of cancer immune ecotherapy that targets the entire tumor ecosystem.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

From immune equilibrium to tumor ecodynamics

Chen

2024

Front. Oncol.

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“…Platelets may promote tumor metastasis via platelet-tumor cell interactions. The interactions create favorable conditions for tumor cell cross-endothelial migration [ 42 ]. Tumor cells activates platelets, which can enhance the formation of platelet-tumor cell aggregates, facilitating subsequent distant metastasis [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Activated platelets release extracellular vesicles and particles containing exosomes, microparticles and some pro-angiogenic contents, such as serotonin [ 44 ], PDGF [ 45 ], VEGF [ 46 ] and GPIbα [ 47 ], which promote HCC proliferation, metastasis, and angiogenesis. Via NK cells and T cells, platelets assist tumor cell immune escape, which is the key to achieve tumor cell metastasis [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet count as a predictor of vascular invasion and extrahepatic metastasis in hepatocellular carcinoma: A systematic review and meta-analysis

Pang,

Gong,

Pan

et al. 2024

Heliyon

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“…Distant metastasis is a significant cause of poor tumor prognosis, and platelets play an essential role in this process. [226][227][228] This function of platelets can be achieved in three ways: 1) stimulating tumor cells so that they acquire invasiveness; 2) binding to circulating tumor cells to assist them in achieving immune escape; 3) helping tumor cells to colonize. Thus, the distant metastasis of of key immune-related molecules.…”

Section: Liposomesmentioning

confidence: 99%

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Chen

Yue

Yang

et al. 2023

Adv Healthcare Materials

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The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, they have found a significant role in improving drug delivery and inhibiting the growth and metastasis of tumor cells. Moreover, recent studies have highlighted their potential in modulating the tumor microenvironment (TME) and enhancing the activity of immune cells to improve tumor therapy efficacy. Various types of nanomaterials are currently utilized as drug carriers, immunosuppressants, immune activators, immunoassay reagents, and more for tumor immunotherapy. Necessarily, nanomaterials used for tumor immunotherapy can be grouped into two categories: organic and inorganic nanomaterials. Though both have shown the ability to achieve the purpose of tumor immunotherapy, their composition and structural properties result in differences in their mechanisms and modes of action. Organic nanomaterials can be further divided into organic polymers, cell membranes, nanoemulsion‐modified, and hydrogel forms. At the same time, inorganic nanomaterials can be broadly classified as nonmetallic and metallic nanomaterials. The current review aims to explore the mechanisms of action of these different types of nanomaterials and their prospects for promoting tumor immunotherapy.This article is protected by copyright. All rights reserved

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Roles of platelets in tumor invasion and metastasis: A review

Cited by 18 publications

References 96 publications

From immune equilibrium to tumor ecodynamics

From immune equilibrium to tumor ecodynamics

Platelet count as a predictor of vascular invasion and extrahepatic metastasis in hepatocellular carcinoma: A systematic review and meta-analysis

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

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