Roles of Plasmacytoid Dendritic Cells in Gastric Cancer

Abstract

Gastric cancer (GC) is the fifth most common neoplasm and the third most deadly cancer in humans worldwide. Helicobacter pylori infection is the most important causative factor of gastric carcinogenesis, and activates host innate and adaptive immune responses. As key constituents of the tumor immune microenvironment, plasmacytoid dendritic cells (pDCs) are increasingly attracting attention owing to their potential roles in immunosuppression. We recently reported that pDCs have vital roles in the development of immunosuppression in GC. Clarifying the contribution of pDCs to the development and progression of GC may lead to improvements in cancer therapy. In this review, we summarize current knowledge regarding immune modulation in GC, especially the roles of pDCs in GC carcinogenesis and treatment strategies.

The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy

“…Although plasmacytoid DC normally exhibit robust IFN-α production following TLR-mediated activation they can lose this function with chronic activation and contribute to an immunosuppressive tumor microenvironment [ 33 ]. Indeed, they have been suggested a potential target for therapy in gastric cancer [ 34 ] and these data indicate that this may also be the case for EAC where it was also noteworthy that they were highly sensitive to chemotherapy.…”

The Single Cell Transcriptional Landscape of Esophageal Adenocarcinoma and Its Modulation by Neoadjuvant Chemotherapy

“…Although plasmacytoid DC normally exhibit robust IFN-α production following TLR-mediated activation they can lose this function with chronic activation and contribute to an immunosuppressive tumor microenvironment (Mitchell et al, 2018). Indeed, they have been suggested a potential target for therapy in gastric cancer (Yang et al, 2022) and these data indicate that this may also be the case for EAC where it was also noteworthy that they were highly sensitive to chemotherapy.…”

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

“…Microbial taxonomic features (MTFs) can be used to predict early gastric neoplasia (EGN; Png et al, 2022 ) and may improve the accuracy of the polygenic risk score (PRS) model in predicting GC ( Wang et al, 2023 ). As for the mechanism, many studies have revealed that non- H. pylori microorganisms promote GC by inducing inflammation, modulating the immune response, triggering DNA damage, and promoting epithelial–mesenchymal transformation ( Yang et al, 2022 ; Liao et al, 2023 ). Gastric non- H. pylori microorganisms may participate in the progression of GC by affecting host DNA methylation ( Yue et al, 2023 ).…”