Roles of PD‐L1 in human adipose‐derived mesenchymal stem cells under inflammatory microenvironment
Jinqiu Sun,
Hannah Zhong,
Bo Kang
et al.
Abstract:Mesenchymal stem cells (MSCs) display unique homing and immunosuppression features which make them promising candidates for cell therapy in inflammatory disorders. It is known that C‐X‐C chemokine receptor type 4 (CXCR4, also known as CD184) is a critical receptor implicated in MSCs migration, and the protein programmed death ligand‐1 (PD‐L1) is involved in MSC's immunosuppression. However, it remains unclear how the molecular mechanisms regulate PD‐L1 expression for migration and immunosuppression of MSCs und… Show more
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