Roles of oral microbiota and oral-gut microbial transmission in hypertension

Chen, Bo‐Yan; Lin, Wei-Ming; Li, Yulin; Bi, Chao; Du, Lin‐Juan; Liu, Yuan; Zhou, Lujun; Liu, Ting; Xu, Shuo; Shi, Chaoji; Zhu, Hong; Wang, Yongli; Sun, Jian‐Yong; Liu, Yan; Zhang, Wu‐Chang; Lü, Haixia; Wang, Yihua; Feng, Qiang; Chen, Fu-xiang; Wang, Changqian; Tonetti, Maurizio S.; Zhu, Yaqin; Zhang, Huili; Duan, Sheng-Zhong

doi:10.1016/j.jare.2022.03.007

Cited by 28 publications

(24 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sample metadata and all clinical parameters are presented in Table S1 in the supplemental material. The procedures of sample collection were consistent with our previous report ( 60 ). Briefly, participants were required to rinse their mouths and avoid eating and drinking for at least an hour before collection of oral samples.…”

Section: Methodsmentioning

confidence: 57%

Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

Chen

Lin

et al. 2023

Microbiol Spectr

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 57%

Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

Chen

Lin

et al. 2023

Microbiol Spectr

Self Cite

View full text Add to dashboard Cite

show abstract

“…The LEFSe analysis showed that the abundance of Actinobacillus, Alloprevotella, Anaerobiospirillum, Prevotella 2, Staphylococcus, Sutterella, and Veillonella in wild macaques, humans, and dogs in the high altitude environments is significantly higher than that in the low altitude environments and has a significant role in indicating high altitude environments, however, in the low altitude environments, no indicator microbiota with a significantly higher relative abundance was found in the three species. Previous studies have found that Actinobacillus is significantly positively correlated with systolic blood pressure in blood pressure regulation (Chen B. Y. et al, 2022).…”

Section: Discussionmentioning

confidence: 91%

Diet and high altitude strongly drive convergent adaptation of gut microbiota in wild macaques, humans, and dogs to high altitude environments

Zhao

Yao²,

Dong³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Animal gut microbiota plays an indispensable role in host adaptation to different altitude environments. At present, little is known about the mechanism of animal gut microbiota in host adaptation to high altitude environments. Here, we selected wild macaques, humans, and dogs with different levels of kinship and intimate relationships in high altitude and low altitude environments, and analyzed the response of their gut microbiota to the host diet and altitude environments. Alpha diversity analysis found that at high altitude, the gut microbiota diversity of wild macaques with more complex diet in the wild environments is much higher than that of humans and dogs with simpler diet (p < 0.05), and beta diversity analysis found that the UniFrac distance between humans and dogs was significantly lower than between humans and macaques (p < 0.05), indicating that diet strongly drive the convergence of gut microbiota among species. Meanwhile, alpha diversity analysis found that among three subjects, the gut microbiota diversity of high altitude population is higher than that of low altitude population (ACE index in three species, Shannon index in dog and macaque and Simpson index in dog, p < 0.05), and beta diversity analysis found that the UniFrac distances among the three subjects in the high altitude environments were significantly lower than in the low altitude environments (p < 0.05). Additionally, core shared ASVs analysis found that among three subjects, the number of core microbiota in high altitude environments is higher than in low altitude environments, up to 5.34 times (1,105/207), and the proportion and relative abundance of the core bacteria types in each species were significantly higher in high altitude environments than in low altitude environments (p < 0.05). The results showed that high altitude environments played an important role in driving the convergence of gut microbiota among species. Furthermore, the neutral community model trial found that the gut microbiota of the three subjects was dispersed much more at high altitude than at low altitude, implying that the gut microbiota convergence of animals at high altitudes may be partly due to the microbial transmission between hosts mediated by human activities.

show abstract

“…The bidirectional relationship between oral and systemic diseases has been documented in many studies [ 55–62 ]; however, the role of oral-gut axis in systemic diseases has been recently proposed [ 63–68 ]. Herein we summarized the contribution of interplay between oral microbiota and gut microbiota to systemic diseases.…”

Section: Oral Microbiota Gut Microbiota and Systemic Diseasesmentioning

confidence: 99%

The interplay between oral microbiota, gut microbiota and systematic diseases

Tan

Wang²,

Gong

2023

Journal of Oral Microbiology

View full text Add to dashboard Cite

Over the past two decades, the importance of microbiota in health and disease has become evident. The human gut microbiota and oral microbiota are the largest and second-largest microbiome in the human body, respectively, and they are physically connected as the oral cavity is the beginning of the digestive system. Emerging and exciting evidence has shown complex and important connections between gut microbiota and oral microbiota. The interplay of the two microbiomes may contribute to the pathological processes of many diseases, including diabetes, rheumatoid arthritis, nonalcoholic fatty liver disease, inflammatory bowel disease, pancreatic cancer, colorectal cancer, and so on. In this review, we discuss possible routes and factors of oral microbiota to affect gut microbiota, and the contribution of this interplay between oral and gut microbiota to systemic diseases. Although most studies are association studies, recently, there have been increasing mechanistic investigations. This review aims to enhance the interest in the connection between oral and gut microbiota, and shows the tangible impact of this connection on human health.

show abstract

Roles of oral microbiota and oral-gut microbial transmission in hypertension

Cited by 28 publications

References 54 publications

Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension

Diet and high altitude strongly drive convergent adaptation of gut microbiota in wild macaques, humans, and dogs to high altitude environments

The interplay between oral microbiota, gut microbiota and systematic diseases

Contact Info

Product

Resources

About