Roles of NRF2 in DNA damage repair

Li, Jiale; Xu, Chang; Liu, Qiang

doi:10.1007/s13402-023-00834-5

Cited by 6 publications

(5 citation statements)

References 97 publications

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“…An appropriate dose of EGCG can activate the NRF2 antioxidant-responsive element pathway to resist any side effects, including DNA damage or cell death. 21,41,42 Our results also demonstrated that ENPs significantly diminish the suppression of body weight and reduce hepatotoxicity and DNA damage; thus, we systematically explored whether the NRF2 pathway is involved in the effect of ENPs. As shown in Fig.…”

Section: Resultsmentioning

confidence: 96%

Formation of EGCG oxidation self-assembled nanoparticles and their antioxidant activity in vitro and hepatic REDOX regulation activity in vivo

Wu,

Wang,

Wang

et al. 2024

Food Funct.

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Section: Resultsmentioning

confidence: 96%

Formation of EGCG oxidation self-assembled nanoparticles and their antioxidant activity in vitro and hepatic REDOX regulation activity in vivo

Wu,

Wang,

Wang

et al. 2024

Food Funct.

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“…These effects protect DNA from damage caused by oxidative stress and toxic agents. In addition, NRF2 is directly implicated in various DNA repair pathways resulting in the maintenance of genome integrity and regulation of cell cycle [87]. In this regard, NRF2 activators hold potential as chemopreventive agents.…”

Section: Nrf2: the Bright Sidementioning

confidence: 99%

The Multifaceted Roles of NRF2 in Cancer: Friend or Foe?

Glorieux,

Enríquez,

González

et al. 2024

Antioxidants

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Physiological concentrations of reactive oxygen species (ROS) play vital roles in various normal cellular processes, whereas excessive ROS generation is central to disease pathogenesis. The nuclear factor erythroid 2-related factor 2 (NRF2) is a critical transcription factor that regulates the cellular antioxidant systems in response to oxidative stress by governing the expression of genes encoding antioxidant enzymes that shield cells from diverse oxidative alterations. NRF2 and its negative regulator Kelch-like ECH-associated protein 1 (KEAP1) have been the focus of numerous investigations in elucidating whether NRF2 suppresses tumor promotion or conversely exerts pro-oncogenic effects. NRF2 has been found to participate in various pathological processes, including dysregulated cell proliferation, metabolic remodeling, and resistance to apoptosis. Herein, this review article will examine the intriguing role of phase separation in activating the NRF2 transcriptional activity and explore the NRF2 dual impacts on tumor immunology, cancer stem cells, metastasis, and long non-coding RNAs (LncRNAs). Taken together, this review aims to discuss the NRF2 multifaceted roles in both cancer prevention and promotion while also addressing the advantages, disadvantages, and limitations associated with modulating NRF2 therapeutically in cancer treatment.

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“…The lethal damage caused by RT is primarily the result of direct DNA damage by ionizing radiation [ 11 ]. It has also been suggested that Nrf-2 can repair radiation-induced DNA damage through the basal excision repair pathway and repair of broken DNA duplexes [ 77 , 78 ]. The basal excision repair pathway has been described in a study by Singh et al Nrf-2 binds to the OGG1 promoter, and Nrf-2 deficiency inhibits OGG1 expression [ 79 ].…”

Section: The Potential Role and Mechanisms Of Nrf-2 In Radiation Indu...mentioning

confidence: 99%

Nrf-2 as a novel target in radiation induced lung injury

Chen,

Wang,

Zuo

et al. 2024

Heliyon

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Roles of NRF2 in DNA damage repair

Cited by 6 publications

References 97 publications

Formation of EGCG oxidation self-assembled nanoparticles and their antioxidant activity in vitro and hepatic REDOX regulation activity in vivo

Formation of EGCG oxidation self-assembled nanoparticles and their antioxidant activity in vitro and hepatic REDOX regulation activity in vivo

The Multifaceted Roles of NRF2 in Cancer: Friend or Foe?

Nrf-2 as a novel target in radiation induced lung injury

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