Roles of Notch1 Signaling in Regulating Satellite Cell Fates Choices and Postnatal Skeletal Myogenesis

Abstract

Adult skeletal muscle stem cells, also called satellite cells, are indispensable for the growth, maintenance, and regeneration of the postnatal skeletal muscle. Satellite cells, predominantly quiescent in mature resting muscles, are activated after skeletal muscle injury or degeneration. Notch1 signaling is an evolutionarily conserved pathway that plays crucial roles in satellite cells homeostasis and postnatal skeletal myogenesis and regeneration. Activation of Notch1 signaling promotes the muscle satellite cells quiescence and proliferation, but inhibits differentiation of muscle satellite cells. Notably, the new roles of Notch1 signaling during late-stage of skeletal myogenesis including in post-differentiation myocytes and post-fusion myotubes have been recently reported. Here, we mainly review and discuss the regulatory roles of Notch1 in regulating satellite cell fates choices and skeletal myogenesis. J. Cell. Physiol. 232: 2964-2967, 2017. © 2016 Wiley Periodicals, Inc.

Integrated Analyses Reveal Overexpressed Notch1 Promoting Porcine Satellite Cells’ Proliferation through Regulating the Cell Cycle

“…In 2016, Shan et al reviewed that activation of Notch1 signaling promotes the muscle satellite cells’ quiescence and proliferation [ 45 ]. To date, several studies have confirmed several specific genes and miRNAs regulating the proliferation of satellite cells through the Notch signaling pathway [ 39 , 40 , 46 ].…”

Di‐(2‐ethylhexyl) phthalate (DEHP)‐induced testicular toxicity through Nrf2‐mediated Notch1 signaling pathway in Sprague–Dawley rats

“…After binding with its ligand, Notch is activated by γ‐secretase‐dependent proteolysis within the transmembrane domain to release the Notch intracellular domain (NICD). Then, the NICD translocates into the nucleus and associates with the constitutive DNA‐binding protein CSL to activate transcription of downstream targets, such as Hes1 and Hes5 . However, the evidence regarding the association between Nrf2 and Notch signaling is inconsistent .…”

“…Then, the NICD translocates into the nucleus and associates with the constitutive DNA-binding protein CSL to activate transcription of downstream targets, such as Hes1 and Hes5. [18][19][20][21] However, the evidence regarding the association between Nrf2 and Notch signaling is inconsistent. 22,23 Furthermore, few studies have investigated this association in the male reproductive system.…”

Effects of Contusion and Exhaustive Exercise on Mg53, PTRF in Skeletal Muscle of Rats

“…[13] On the other hand, roles of Notch1 Signaling in regulating satellite cell fates choices and postnatal skeletal myogenesis had been confirmed, and human skeletal muscle fibroblasts can stimulate in vitro myogenesis and in vivo muscle regeneration. 26 Wnt/β-catenin signalling also paly a important role to promote stem cells to repair injured tissue. In a previous in vitro study, the results showed that the canonical Wnt/β-catenin pathway promoted the differentiation of Mesenchymal stem cells (MSCs) into type II alveolar epithelial cells.…”