Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

Balandeh, Ebrahim; Mohammadshafie, Kimia; Mahmoudi, Yaser; Pourhanifeh, Mohammad Hossein; Rajabi, Ali; Bahabadi, Zahra Razaghi; Mohammadi, Amir Hossein; Rahimian, Neda; Hamblin, Michael R.; Mirzaei, Hamed

doi:10.3389/fcell.2021.716462

Cited by 44 publications

(27 citation statements)

References 146 publications

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“…Non-coding RNAs, including microRNA (miRNA), long-chain non-coding RNA (lncRNA), small interference RNA (siRNA), and circular RNA (circRNA) are known to make up more than 75% of the genome transcripts and regulate various physiological processes during development and tumorigenesis 7 , 8 . These regulatory functions are brought about through the interaction of these non-coding RNAs with several other signaling pathways 9 , 10 . In the past decade, convincing evidence has accumulated in regards to the roles of non-coding RNAs, in particular circRNAs, in a wide range of physiological processes, as well as the pathogenesis of various diseases including cancer 11 .…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Qadir¹,

Li²,

Yang³

2022

Theranostics

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The Hippo signaling pathway is an evolutionarily conserved network that regulates organ size and tissue homeostasis in mammals. This pathway controls various cell functions, such as growth, proliferation, survival, apoptosis, and stemness by switching 'on' or 'off' its inhibitory and/or transcriptional module, thereby regulating target gene(s) expression. Altered Hippo signaling has been implicated in various forms of cancers. Increasing evidence suggests cross-talk between the Hippo signaling pathway and non-coding RNAs, in particular circular RNAs (circRNAs). In this context, the current review presents the mechanistic interplay between the Hippo pathway and related circRNAs in various forms of cancers, along with the capabilities of these circRNAs to function either as tumor suppressors or oncogenes through miRNA sponging or protein binding mechanisms. Furthermore, we discuss the constraints and limitations in circRNA mechanistic studies while highlighting some outstanding questions regarding the roles of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, we delineate the potential of these circRNAs to be employed as diagnostic and prognostic biomarkers, as well as molecular hotspots for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Qadir¹,

Li²,

Yang³

2022

Theranostics

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“…MicroRNAs regulating angiogenesis in cancers have been dubbed angiomiRNAs [ 85 , 86 ]. Several angiomiRNAs have been identified in glioblastomas [ 87 ], with some originating from glioblastoma-derived EVs [ 88 ]. However, studies indicating the relationship between angiomiRNAs and the EMT process in glioblastomas are limited.…”

Section: Mirna-emt-related Angiogenesismentioning

confidence: 99%

MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma

Damane

Hull

Reis

et al. 2022

Genes

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MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translation of messenger RNA (mRNA) into proteins. Circulating miRNAs have attracted attention as possible prognostic markers of cancer, which could aid in the early detection of the disease. Epithelial to mesenchymal transition (EMT) has been implicated in tumorigenic processes, primarily by promoting tumor invasiveness and metastatic activity; this is a process that could be manipulated to halt or prevent brain metastasis. Studies show that miRNAs influence the function of EMT in glioblastomas. Thus, miRNA-related EMT can be exploited as a potential therapeutic target in glioblastomas. This review points out the interrelation between miRNA and EMT signatures, and how they can be used as reliable molecular signatures for diagnostic purposes or targeted therapy in glioblastomas.

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“…Tumor cells are capable of promoting angiogenesis or even differentiating into endothelial cells to form new vessels ( Pezzella et al, 2015 ; Wang et al, 2020b ). Recent advances reported that many lncRNAs are involved in mediating the abnormal angiogenesis of GBM ( Balandeh et al, 2021 ). For instance, Jia et al (2016) characterized that H19 promotes glioma-associated endothelial cell (GEC) growth and the formation of the tube through sponging miR-29a, thereby promoting angiogenic factor VASH2 expression and angiogenesis.…”

Section: Significance Of Lncrnas In Gbm Malignant Phenotypesmentioning

confidence: 99%

Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma

Liu

Chen

Wang

et al. 2022

Front. Cell Dev. Biol.

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Glioblastoma (GBM) is one of the most prevalent and aggressive cancers worldwide. The overall survival period of GBM patients is only 15 months even with standard combination therapy. The absence of validated biomarkers for early diagnosis mainly accounts for worse clinical outcomes of GBM patients. Thus, there is an urgent requirement to characterize more biomarkers for the early diagnosis of GBM patients. In addition, the detailed molecular basis during GBM pathogenesis and oncogenesis is not fully understood, highlighting that it is of great significance to elucidate the molecular mechanisms of GBM initiation and development. Recently, accumulated pieces of evidence have revealed the central roles of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of GBM by binding with DNA, RNA, or protein. Targeting those oncogenic lncRNAs in GBM may be promising to develop more effective therapeutics. Furthermore, a better understanding of the biological function and underlying molecular basis of dysregulated lncRNAs in GBM initiation and development will offer new insights into GBM early diagnosis and develop novel treatments for GBM patients. Herein, this review builds on previous studies to summarize the dysregulated lncRNAs in GBM and their unique biological functions during GBM tumorigenesis and progression. In addition, new insights and challenges of lncRNA-based diagnostic and therapeutic potentials for GBM patients were also introduced.

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Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

Cited by 44 publications

References 146 publications

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma

Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma

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