Roles of Nebulizers in Analytical Chemistry

Canals, Antonio; Aguirre, Miguel

doi:10.1002/9780470027318.a9391

Encyclopedia of Analytical Chemistry 2015

DOI: 10.1002/9780470027318.a9391

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Roles of Nebulizers in Analytical Chemistry

Antonio Canals

Miguel Aguirre

Abstract: Nebulizers offer a wide range of applications in the field of analytical chemistry. This article is a general and comprehensive overview that addresses the most common principles of nebulization and their main and most recent applications in chemical analysis.

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Cited by 3 publications

References 300 publications

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Aerosol assisted synthesis of a pH responsive curcumin anticancer drug nanocarrier using chitosan and alginate natural polymers

Asadi,

Madrakian,

Ahmadi

et al. 2023

Sci Rep

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In recent years, several nanocarrier synthesis methods have been developed. In cancer therapy, the use of smart nanocarriers is of interest. Smart nanocarriers respond to their environment and can release their cargo in a controlled manner under the action of internal or external stimuli. In this work, we report on the development of an aerosol-assisted method for the synthesis of curcumin-loaded chitosan/alginate-based polymeric nanocarrier (CurNCs). A custom-fabricated multi-nebulizer system was utilized for the synthesis of CurNCs. The developed system comprises three main parts a sprayer, an electric heater tunnel, and a collector. Curcumin and chitosan solutions were sprayed using a pneumatic multinebulizer into the electric heater tunnel to form chitosan-curcumin assemblies. Then, the aerosol was guided into the collector solution containing sodium alginate and tri-poly phosphate aqueous solution for further cross-linkage. The synthesized CurNCs were characterized using TEM, DLS, and FTIR techniques. The TEM size of the nanoparticles was 8.62 ± 2.25 nm. The release experiments revealed that the nanocarrier is sensitive to the environment pH as more curcumin is released at acidic pH values (as is the case for cancerous tissues) compared to physiological pH. The curcumin content of the nanocarrier was 77.27 mg g−1 with a drug loading efficiency of 62%. The in-vitro cytotoxicity of the synthesized nanocarrier was evaluated against the MCF7 breast cancer cell line. The IC50 concentrations for CurNCs and curcumin were obtained as 14.86 and 16.45 mg mL−1, respectively. The results showed that while the empty nanocarrier shows non-significant cytotoxicity, the CurNCs impact the cell culture and cause prolonged cell deaths. Overall, pH-responsive curcumin polymeric nanocarrier was synthesized using a custom fabricated aerosol-based method. The method enabled fast and feasible synthesis of the nanocarrier with high efficiency.

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Aerosol assisted synthesis of a pH responsive curcumin anticancer drug nanocarrier using chitosan and alginate natural polymers

Asadi,

Madrakian,

Ahmadi

et al. 2023

Sci Rep

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Aerosol dilution for the introduction of complex matrix samples in plasma-based spectrometry techniques: a tutorial review

Duyck

Peixoto

Rocha

et al. 2022

J. Anal. At. Spectrom.

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Determination of Cd, Pb and Zn in Polymers by Laser Ablation Microwave Induced Plasma Optical Emission Spectrometry

Ślachciński

Janeda

Matusiewicz

2023

Ecological Chemistry and Engineering S

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The potential of laser ablation microwave induced plasma optical emission spectrometry (LA-MIP OES) for the analysis of plastic materials has been investigated. Inorganic species, e.g., metals may be added to them as additives, anti-oxidising agents, stabilisers, plasticisers, colorants and catalytic residues, contaminants and may be present in a wide range of concentrations. The study revealed elevated content of trace elements (Cd, Pb and Zn) which are components of poly(vinyl chloride) (PVC) and polyethylene (PE). Laser ablation using wavelengths of 266 nm as a sampling method for MIP OES was used. The result achieved using elaborated system were compared with those obtained after polymer samples decomposition in high pressure-temperature focused microwave heating digestion system and standard sample pneumatic nebulisation (PN) to MIP OES spectrometer. The calibration strategy using cellulose pellets as support for qualitative analysis for element determination in polymers by LA-MIP OES was proposed. This analytical performance of the LA-MIP OES system was characterised by a determination of the limits of detection (LODs) and precision (RSDs) for elements tested. The experimental concentration detection limits for simultaneous determination, calculated as the concentration giving a signal equal to three times of the standard deviation of the blank (LOD, 3σblank criterion, peak height) were 2 µg g−1, 3 µg g−1 and 5 µg g−1 for Cd, Pb and Zn, respectively. The method offers relatively good precision (RSD ranged from 3 % to 5 %) for micro sampling analysis.

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Roles of Nebulizers in Analytical Chemistry

Abstract: Nebulizers offer a wide range of applications in the field of analytical chemistry. This article is a general and comprehensive overview that addresses the most common principles of nebulization and their main and most recent applications in chemical analysis.

Cited by 3 publications

References 300 publications

Aerosol assisted synthesis of a pH responsive curcumin anticancer drug nanocarrier using chitosan and alginate natural polymers

Aerosol assisted synthesis of a pH responsive curcumin anticancer drug nanocarrier using chitosan and alginate natural polymers

Aerosol dilution for the introduction of complex matrix samples in plasma-based spectrometry techniques: a tutorial review

Determination of Cd, Pb and Zn in Polymers by Laser Ablation Microwave Induced Plasma Optical Emission Spectrometry

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